Sunil Chauhan, PhD

Researchers identify factors responsible for chronic nature of autoimmune disease

Researchers identify factors responsible for chronic nature of autoimmune disease

January 4, 2017

Boston, Mass. — Researchers from Schepens Eye Research Institute of Massachusetts Eye and Ear have uncovered two factors responsible for the chronic, lifelong nature of autoimmune disorders, which tend to “flare up” intermittently in affected patients. These two factors are cell-signaling proteins called cytokines—specifically Interleukin-7 and -15 (IL-7 and IL-15)—that are secreted by cells of the immune system and help modulate memory Th17 cells, a subset of T cells which are known to contribute to autoimmune disorders. Until now, it was unclear how Th17 cells...

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Researchers shed light on repair mechanism for severe corneal injuries

Researchers shed light on repair mechanism for severe corneal injuries

October 3, 2016

New findings may pave the way for the development of pharmaceutical therapies to reverse corneal scarring

Boston, Mass. —  In cases of severe ocular trauma involving the cornea, wound healing occurs following intervention, but at the cost of opaque scar tissue formation and damaged vision. Recent research has shown that mesenchymal stem cells (MSCs) — which can differentiate into a variety of cells, including bone, cartilage, muscle and fat cells — are capable of returning clarity to scarred corneas; however, the mechanisms by which...

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