Patricia A. D'Amore, PhD, MBA

Patricia A. D'Amore, PhD, MBA

Charles L. Schepens Professor of Ophthalmology
Patricia A. D'Amore, PhD, MBA

Research Area(s): AMDDiabetic Eye Disease
Director, Howe Laboratory

Associate Chief of Basic and Translational Research
Co-Director, AMD Center of Excellence
MGH ECOR Ophthalmology Representative, Mass. Eye and Ear
Senior Scientist, Schepens Eye Research Institute

Websites:
Harvard Catalyst Profile
Mass. Eye and Ear Profile
Schepens Eye Research Institute Profile

BIOGRAPHY

Patricia A. D’Amore grew up in Everett, Massachusetts and received a PhD in biology from Boston University in 1977. She conducted postdoctoral research in the Department of Ophthalmology and the Department of Physiological Chemistry at Johns Hopkins University School of Medicine, where she was appointed Instructor in 1979 and Assistant Professor in 1980.

Dr. D’Amore returned to Boston in 1981 to join Dr. Judah Folkman in the Program in Vascular Biology at Boston Children’s Hospital (then the Surgical Research Laboratories), where she has since served as a Research Associate in the Department of Surgery. Additionally, she obtained an MBA from Northeastern University In 1987. At Harvard Medical School, Dr. D’Amore was appointed Associate Professor of Pathology in 1989. In 1998 she became Professor of Ophthalmology at Harvard Medical School, and also joined Schepens Eye Research Institute (an affiliate of Harvard Medical School) as a Senior Scientist. In 2012 she was appointed the Charles L. Schepens Professor of Ophthalmology at Harvard Medical School and Director of Research at the Schepens Eye Research Institute of Mass. Eye and Ear. In 2014 she was appointed Professor of Pathology at Harvard Medical School; she was also appointed Director of the Howe Laboratory and the Associate Chief for Ophthalmology Basic and Translational Research in the Department of Ophthalmology.

Dr. D’Amore is an internationally recognized expert of vascular growth and development, and has been at the forefront of angiogenesis research for over three decades. Among her foremost transformative contributions is the identification of vascular endothelial growth factor (VEGF) as the elusive “Factor X” that causes pathological blood vessel growth in blinding neovascular eye diseases. These investigations formed the scientific foundations of anti-VEGF therapies, which were first approved for clinical use in 2004 and are currently used to treat various cancers and intraocular vascular diseases such as diabetic retinopathy and age-related macular degeneration (AMD). Dr. D’Amore also developed a widely used mouse model of oxygen-induced retinopathy, which has served as the cornerstone of many basic scientific investigations of vascular development and preclinical studies of vascular-targeting agents. More recently, Dr. D’Amore’s studies have also uncovered important physiological roles of vascular growth factors — yielding crucial insight into the safe use of anti-angiogenic therapies. Her current research focuses on understanding the regulation of the development and stabilization of the microvasculature. She is also investigating the pathogenesis of AMD with a focus on inflammation.

She has published more than 140 peer-reviewed papers, 64 reviews, and is editor or co-editor of four books. She is the recipient of numerous awards and honors, including the Alcon Research Institute Award, the Cogan Award, the A. Clifford Barger Excellence in Mentoring Award, the Everett Mendelsohn Excellence in Mentoring Award, the Rous-Whipple Award, and the Endre A. Balazs Award. Dr. D’Amore is a Gold Fellow in the Association for Research in Vision and Ophthalmology (ARVO) and is the recipient of the 2015 Proctor Medal, one of ARVO’s highest honors, which recognizes outstanding research in ophthalmology.

Click here to read the latest news about Patricia A. D'Amore, PhD, MBA

Centers of Excellence and Institutes

All Faculty (Alphabetical by Last Name)