Citation:
Barhoumi A, Salvador-Culla B, Kohane DS. NIR-Triggered Drug Delivery by Collagen-Mediated Second Harmonic Generation. Adv Healthc Mater 2015;4(8):1159-63.
Date Published:
2015 JunAbstract:
Second harmonic generation is a process through which nonlinear materials such as collagen can absorb two photons and scatter one with twice the energy. Collagen upconverts 730 nm (near-IR) to 365 nm (UV) through second harmonic generation, which cleaves a molecule bound to collagen via a UV-sensitive linker.