Altered cholesterol homeostasis in aged macrophages linked to neovascular macular degeneration

Date Published:

2013 Apr 02


Abnormal lipid metabolism has been linked to age-related macular degeneration (AMD); choroidal neovascularization in late AMD commonly causes blindness. Sene et al. (2013) now demonstrate that in aged macrophages decreased ABCA1 expression, regulated by liver X receptor and miR-33, impairs export of intracellular cholesterol, which promotes neovascular AMD.

Last updated on 12/08/2018