Bilateral Sequential Dacryocystitis in a Patient With Graft-Versus-Host Disease.

Citation:

Campbell AA, Jakobiec FA, Rashid A, Dana R, Yoon MK. Bilateral Sequential Dacryocystitis in a Patient With Graft-Versus-Host Disease. Ophthal Plast Reconstr Surg 2016;32(4):e89-92.

Date Published:

2016 Jul-Aug

Abstract:

A 29-year-old woman with a history of 2 bone marrow transplants for acute myelogenous leukemia developed bilateral sequential dacryocystitis in the context of known ocular graft-versus-host disease. With each infection, the patient underwent uneventful dacryocystorhinostomy. Postoperatively, she developed severe dry eye disease requiring replacement of punctal plugs and use of a prosthetic replacement of the ocular surface ecosystem lens. Histopathologic and immunohistochemical examination of the lacrimal sac showed a dense diffuse nonfollicular lymphocytic subepithelial infiltrate in the lacrimal sac that contained moderately more T-cells than B-cells. This is the first report of acute dacryocystitis associated with graft-versus-host disease. The authors caution that similar patients may develop worsening of ocular surface dryness due to restoration of normal lacrimal outflow.

Last updated on 08/12/2016