@article {1078731,
	title = {Outcomes in Autoimmune Retinopathy Patients Treated With Rituximab},
	journal = {Am J Ophthalmol},
	volume = {180},
	year = {2017},
	month = {2017 Aug},
	pages = {124-132},
	abstract = {PURPOSE: To evaluate clinical and ancillary testing, including adaptive optics, outcomes in autoimmune retinopathy (AIR) patients treated with rituximab. DESIGN: Retrospective, interventional case series. METHODS: patients: Sixteen AIR patients treated with rituximab. OBSERVATION PROCEDURES: All patients were treated with a loading and maintenance dose schedule of intravenous rituximab. Visual acuity (VA), electroretinography (ERG), and spectral-domain optical coherence tomography (SDOCT) and visual field (VF) results were recorded. A subset of patients was also imaged using adaptive optics scanning laser ophthalmoscopy (AO-SLO). MAIN OUTCOME MEASURES: Rates of VA change before vs after rituximab initiation were compared with mixed-model linear regression. RESULTS: The rate of visual decline was significantly less after rituximab initiation compared with the rate of visual decline prior to rituximab initiation (P\&nbsp;= .005). Seventy-seven percent of eyes had stable or improved VA 6\&nbsp;months after rituximab initiation. Amplitudes and implicit times on ERG, mean deviation on VF, central subfield mean thickness, and total macular volume did not decrease to a significant degree over the rituximab treatment period. Six eyes had serial AO-SLO imaging. Cone densities did not change significantly over the treatment period. CONCLUSION: VA was stable or improved in a majority of AIR patients while they were being treated with rituximab. OCT and ERG parameters, as well as AO-SLO cone densities, were stable during treatment. Studies with additional patients and longer follow-up periods are needed to further explore the utility of rituximab in the management of AIR.},
	keywords = {Adult, Aged, Autoantibodies, Autoimmune Diseases, Electroretinography, Female, Humans, Immunologic Factors, Intravitreal Injections, Male, Middle Aged, Ophthalmoscopy, Outcome Assessment (Health Care), Retina, Retinal Diseases, Retrospective Studies, Rituximab, Tomography, Optical Coherence, Visual Acuity, Visual Fields},
	issn = {1879-1891},
	doi = {10.1016/j.ajo.2017.04.019},
	author = {Davoudi, Samaneh and Ebrahimiadib, Nazanin and Yasa, Cagla and Sevgi, Damla D and Roohipoor, Ramak and Papavasilieou, Evangelia and Comander, Jason and Sobrin, Lucia}
}
