@article {1078846,
	title = {PROGRESSIVE RETINAL DETACHMENT IN INFANTS WITH RETINOPATHY OF PREMATURITY TREATED WITH INTRAVITREAL BEVACIZUMAB OR RANIBIZUMAB},
	journal = {Retina},
	volume = {38},
	number = {6},
	year = {2018},
	month = {2018 Jun},
	pages = {1079-1083},
	abstract = {PURPOSE: Fibrovascular contraction and tractional retinal detachment (TRD) are recognized complications associated with the use of anti-vascular endothelial growth factor agents in vasoproliferative vitreoretinopathies. The authors characterize TRDs that developed after intravitreal bevacizumab or ranibizumab therapy for vascularly active retinopathy of prematurity.

METHODS: This is an international, multicenter, interventional, retrospective, case series. Thirty-five eyes from 23 infants were included. Inclusion required anti-vascular endothelial growth factor treatment of Type 1 retinopathy of prematurity with progression to TRD.

RESULTS: Mean gestational age was 26 {\textpm} 2 weeks, and mean birth weight was 873 {\textpm} 341 g. Mean postmenstrual age on the day of injection was 35 {\textpm} 2 weeks. Retinal detachment was noted a mean of 70 days (median, 34; range, 4-335) after injection. Eleven percent detached within 1 week, 23\% within 2 weeks, and 49\% within 4 weeks. The highest stage of retinopathy of prematurity noted was 4A in 29\%, 4B in 37\%, and 5 in 34\% of eyes. Time to RD negatively correlated with postmenstrual age at the time of injection (Rho = -0.54; P < 0.01). Three TRD configurations were observed: 1) conventional peripheral elevated ridge or volcano-shaped Stage 5 detachment, 2) midperipheral detachment with tight circumferential vectors, and 3) very posterior detachment with prepapillary contraction. Full or partial reattachment was achieved with surgical intervention in 86\% of eyes.

CONCLUSION: Progressive atypical TRD may occur after anti-vascular endothelial growth factor injections for retinopathy of prematurity. The configuration of the detachment varies with the extent of primary retinal vascularization present at the time of treatment.},
	issn = {1539-2864},
	doi = {10.1097/IAE.0000000000001685},
	author = {Yonekawa, Yoshihiro and Wu, Wei-Chi and Nitulescu, Cristina E and Chan, R V Paul and Thanos, Aristomenis and Thomas, Benjamin J and Todorich, Bozho and Drenser, Kimberly A and Trese, Michael T and Capone, Antonio}
}
