@article {1109786,
	title = {IFN-γ-Expressing Th17 Cells Are Required for Development of Severe Ocular Surface Autoimmunity},
	journal = {J Immunol},
	volume = {199},
	number = {3},
	year = {2017},
	month = {2017 Aug 01},
	pages = {1163-1169},
	abstract = {Th17 cells are critical effectors mediating the ocular surface autoimmunity in dry eye disease (DED). Increased IFN-γ has also been implicated in DED; however, it remains unclear to what extent Th1 cells contribute to DED pathogenesis. In this study, we investigated the cellular source of IFN-γ and assessed its contribution to corneal epitheliopathy in DED mice. We discovered a significant IL-17A(+)IFN-γ(+) (Th17/1) population and determined that these cells are derived from Th17 precursors. Adoptive transfer of Th17/1, but not Th1, cells confers the disease to naive recipients as effectively as do Th17 cells alone. DED-induced IL-12 and IL-23 are required for in vivo transition of pathogenic Th17 cells to IFN-γ producers. Furthermore, using IFN-γ-deficient Th17 cells, we demonstrate the disease-amplifying role of Th17-derived IFN-γ in DED pathogenesis. These results clearly demonstrate that Th17 cells mediate ocular surface autoimmunity through both IL-17A and IFN-γ.},
	issn = {1550-6606},
	doi = {10.4049/jimmunol.1602144},
	author = {Chen, Yihe and Chauhan, Sunil K and Shao, Chunyi and Omoto, Masahiro and Inomata, Takenori and Dana, Reza}
}
