@article {1138376,
	title = {Sox11 Expression Promotes Regeneration of Some Retinal Ganglion Cell Types but Kills Others},
	journal = {Neuron},
	volume = {94},
	number = {6},
	year = {2017},
	month = {2017 Jun 21},
	pages = {1112-1120.e4},
	abstract = {At least 30 types of retinal ganglion cells (RGCs) send\&nbsp;distinct messages through the optic nerve to the brain. Available strategies of promoting axon regeneration act on only some of these types. Here\&nbsp;we tested the hypothesis that overexpressing developmentally important transcription factors in adult RGCs could reprogram them to a "youthful" growth-competent state and promote regeneration\&nbsp;of other types. From a screen of transcription factors, we identified Sox11 as one that could induce\&nbsp;substantial axon regeneration. Transcriptome\&nbsp;profiling indicated that Sox11 activates genes involved in cytoskeletal remodeling and axon growth. Remarkably, α-RGCs, which preferentially regenerate following treatments such as Pten deletion, were killed by Sox11 overexpression. Thus, Sox11 promotes regeneration of non-α-RGCs, which are refractory to Pten deletion-induced regeneration.\&nbsp;We conclude that Sox11 can reprogram adult RGCs to a growth-competent state, suggesting that different growth-promoting interventions promote regeneration in distinct neuronal types.},
	keywords = {Animals, Axons, Cell Survival, Gene Expression Profiling, Mice, Microscopy, Fluorescence, Nerve Regeneration, Neuronal Outgrowth, Optic Nerve Injuries, PTEN Phosphohydrolase, Regeneration, Retina, Retinal Ganglion Cells, SOXC Transcription Factors},
	issn = {1097-4199},
	doi = {10.1016/j.neuron.2017.05.035},
	author = {Norsworthy, Michael W and Bei, Fengfeng and Kawaguchi, Riki and Wang, Qing and Tran, Nicholas M and Li, Yi and Brommer, Benedikt and Zhang, Yiming and Wang, Chen and Sanes, Joshua R and Coppola, Giovanni and He, Zhigang}
}
