@article {1179156,
	title = {Association of Disease Location and Treatment With Survival in Diffuse Large B-Cell Lymphoma of the Eye and Ocular Adnexal Region},
	journal = {JAMA Ophthalmol},
	volume = {135},
	number = {10},
	year = {2017},
	month = {2017 Oct 01},
	pages = {1062-1068},
	abstract = {Importance: Primary diffuse large B-cell lymphoma (DLBCL) of the ocular region is rare, and the utility of surgery and radiation therapy remains unresolved. Objective: To explore the clinical characteristics and determine factors associated with overall survival in primary vitreoretinal lymphoma (PVRL) and ocular adnexal (OA)-uveal DLBCL. Design, Setting, and Participants: This retrospective analysis included 396 patients with ophthalmic DLBCL from January 1, 1973, through December 31, 2014, using the Surveillance, Epidemiology, and End Results database. The median follow-up was 39.0 months (interquartile range, 5.1-72.9 months). All patients diagnosed with primary DLBCL of the eye or retina (PVRL) or the eyelid, conjunctiva, choroid, ciliary body, lacrimal gland, or orbit (OA-uveal lymphoma) were included. Patients diagnosed at autopsy or with additional neoplastic disease were excluded. Main Outcomes and Measures: Patient demographic characteristics, disease location, treatment modalities, and overall survival. Results: Forty-seven patients with PVRL (24 women [51.1\%] and 23 men [48.9\%]) and 349 with OA-uveal DLBCL (192 women [55.0\%] and 157 men [45.0\%]) had a similar mean (SD) age at diagnosis (69.6 [12.3] vs 66.1 [17.7] years). No difference in the use of surgery or radiation therapy by location was found. For all PVRL and OA-uveal DLBCL, a Cox proportional hazards regression model affirmed that age older than 60 years was associated with increased risk for death (hazard ratio [HR], 2.7; 95\% CI, 1.9-4.0; P \&lt; .001). Gross total resection was associated with a decreased risk for death (HR, 0.5; 95\% CI, 0.3-0.9; P = .04), whereas radiation therapy was not. The 5-year overall survival among patients with PVRL was 41.4\% (SE, 8.6\%); among those with OA-uveal DLBCL, 59.1\% (SE, 2.8\%; Mantel-Cox test, P = .007). Median overall survival was lower in PVRL (38.0 months; 95\% CI, 14.2-61.8 months) than in OA-uveal DLBCL (96.0 months; 95\% CI, 67.3-124.7 months; Mantel-Cox test, P = .007). In addition, median overall survival in ophthalmic-only disease was higher (84.0 months; 95\% CI, 63.2-104.8 months) than that in primary DLBCL that occurred outside the central nervous system and ophthalmic regions (46.0 months; 95\% CI, 44.4-47.6 months; Mantel-Cox test, P \&lt; .001). Conclusions and Relevance: The 5-year survival in PVRL vs OA-uveal DLBCL differed by 17.7\%, and overall survival was greater in ophthalmic DLBCL than in DLBCL located outside the central nervous system and ophthalmic regions. Younger age (<=60 years) and gross total resection were associated with increased survival.},
	issn = {2168-6173},
	doi = {10.1001/jamaophthalmol.2017.3286},
	author = {Ahmed, Aseef H and Foster, C Stephen and Shields, Carol L}
}
