@article {1179166,
	title = {Implementing higher oxygen saturation targets reduced the impact of poor weight gain as a predictor for retinopathy of prematurity},
	journal = {Acta Paediatr},
	volume = {107},
	number = {5},
	year = {2018},
	month = {2018 May},
	pages = {767-773},
	abstract = {AIM: This study evaluated poor weight gain as a risk factor for infants who required treatment for retinopathy of prematurity (ROP), by comparing those born before and after the implementation of higher oxygen saturation (SpO ) targets at the Queen Silvia Children{\textquoteright}s Hospital, Gothenburg, Sweden.

METHODS: We compared infants born at less than 31 weeks, who were screened and, or, treated for ROP: 127 in 2011-2012 when SpO targets were 88-92\% and 142 in 2015-2016 when they were 91-95\%. The subjects were reviewed for birth characteristics, weekly weight and ROP treatment. Data were analysed using the weight, insulin-like growth factor 1, neonatal, ROP (WINROP) prediction tool.

RESULTS: The 2011-2012 infants who needed ROP treatment (12.6\%) had significantly poorer postnatal weight gain than those who did not, but this was not seen in the treated (17.6\%) and nontreated ROP groups in 2015-2016. WINROP sensitivity decreased from 87.5\% in 2011-12 to 48\% in 2015-2016.

CONCLUSION: After the SpO target range was increased from 88-92\% to 91-95\%, postnatal weight gain was no longer a significant risk factor and WINROP lost its ability~to~predict ROP requiring treatment. Risk factors clearly change as neonatal care develops.},
	issn = {1651-2227},
	doi = {10.1111/apa.14049},
	author = {Lundgren, Pia and H{\r a}rd, Anna-Lena and Wilde, {\r A}sa and L{\"o}fqvist, Chatarina and Smith, Lois E H and Hellstr{\"o}m, Ann}
}
