@article {1195221,
	title = {Use of the Controlled Adverse Environment (CAE) in Clinical Research: A Review},
	journal = {Ophthalmol Ther},
	volume = {6},
	number = {2},
	year = {2017},
	month = {2017 Dec},
	pages = {263-276},
	abstract = {The many internal and external factors that contribute to the pathophysiology of dry eye disease (DED) create a difficult milieu for its study and complicate its clinical diagnosis and treatment. The controlled adverse environment (CAE{\textregistered}) model has been developed to minimize the variability that arises from exogenous factors and to exacerbate the signs and symptoms of DED by stressing the ocular surface in a safe, standardized, controlled, and reproducible manner. By integrating sensitive, specific, and clinically relevant endpoints, the CAE has proven to be a unique and adaptable model for both identifying study-specific patient populations with modifiable signs and symptoms, and for tailoring the evaluation of interventions in clinical research studies.},
	issn = {2193-8245},
	doi = {10.1007/s40123-017-0110-x},
	author = {Ousler, George W and Rimmer, David and Smith, Lisa M and Abelson, Mark B}
}
