@article {1263296,
	title = {Genetic correlations between intraocular pressure, blood pressure and primary open-angle glaucoma: a multi-cohort analysis},
	journal = {Eur J Hum Genet},
	volume = {25},
	number = {11},
	year = {2017},
	month = {2017 Nov},
	pages = {1261-1267},
	abstract = {Primary open-angle glaucoma (POAG) is the most common chronic optic neuropathy worldwide. Epidemiological studies show a robust positive relation between intraocular pressure (IOP) and POAG and modest positive association between IOP and blood pressure (BP), while the relation between BP and POAG is controversial. The International Glaucoma Genetics Consortium (n=27 558), the International Consortium on Blood Pressure (n=69 395), and the National Eye Institute Glaucoma Human Genetics Collaboration Heritable Overall Operational Database (n=37 333), represent genome-wide data sets for IOP, BP traits and POAG, respectively. We formed genome-wide significant variant panels for IOP and diastolic BP and found a strong relation with POAG (odds ratio and 95\% confidence interval: 1.18 (1.14-1.21), P=1.8 {\texttimes} 10-27) for the former trait but no association for the latter (P=0.93). Next, we used linkage disequilibrium (LD) score regression, to provide genome-wide estimates of correlation between traits without the need for additional phenotyping. We also compared our genome-wide estimate of heritability between IOP and BP to an estimate based solely on direct measures of these traits in the Erasmus Rucphen Family (ERF; n=2519) study using Sequential Oligogenic Linkage Analysis Routines (SOLAR). LD score regression revealed high genetic correlation between IOP and POAG (48.5\%, P=2.1 {\texttimes} 10-5); however, genetic correlation between IOP and diastolic BP (P=0.86) and between diastolic BP and POAG (P=0.42) were negligible. Using SOLAR in the ERF study, we confirmed the minimal heritability between IOP and diastolic BP (P=0.63). Overall, IOP shares genetic basis with POAG, whereas BP has limited shared genetic correlation with IOP or POAG.},
	issn = {1476-5438},
	doi = {10.1038/ejhg.2017.136},
	author = {Aschard, Hugues and Kang, Jae H and Iglesias, Adriana I and Hysi, Pirro and Cooke Bailey, Jessica N and Khawaja, Anthony P and Allingham, R Rand and Ashley-Koch, Allison and Lee, Richard K and Moroi, Sayoko E and Brilliant, Murray H and Wollstein, Gadi and Schuman, Joel S and Fingert, John H and Budenz, Donald L and Realini, Tony and Gaasterland, Terry and Scott, William K and Singh, Kuldev and Sit, Arthur J and Igo, Robert P and Song, Yeunjoo E and Hark, Lisa and Ritch, Robert and Rhee, Douglas J and Gulati, Vikas and Haven, Shane and Vollrath, Douglas and Zack, Donald J and Medeiros, Felipe and Weinreb, Robert N and Cheng, Ching-Yu and Chasman, Daniel I and Christen, William G and Pericak-Vance, Margaret A and Liu, Yutao and Kraft, Peter and Richards, Julia E and Rosner, Bernard A and Hauser, Michael A and International Glaucoma Genetics Consortium and Klaver, Caroline C W and van Duijn, Cornelia M and Haines, Jonathan and Wiggs, Janey L and Pasquale, Louis R}
}
