@article {1263331,
	title = {Photoreceptor glucose metabolism determines normal retinal vascular growth},
	journal = {EMBO Mol Med},
	volume = {10},
	number = {1},
	year = {2018},
	month = {2018 Jan},
	pages = {76-90},
	abstract = {The neural cells and factors determining normal vascular growth are not well defined even though vision-threatening neovessel growth, a major cause of blindness in retinopathy of prematurity (ROP) (and diabetic retinopathy), is driven by delayed normal vascular growth. We here examined whether hyperglycemia and low adiponectin (APN) levels delayed normal retinal vascularization, driven primarily by dysregulated photoreceptor metabolism. In premature infants, low APN levels correlated with hyperglycemia and delayed retinal vascular formation. Experimentally in a neonatal mouse model of postnatal hyperglycemia modeling early ROP, hyperglycemia caused photoreceptor dysfunction and delayed neurovascular maturation associated with changes in the APN pathway; recombinant mouse APN or APN receptor agonist AdipoRon treatment normalized vascular growth. APN deficiency decreased retinal mitochondrial metabolic enzyme levels particularly in photoreceptors, suppressed retinal vascular development, and decreased photoreceptor platelet-derived growth factor (Pdgfb). APN pathway activation reversed these effects. Blockade of mitochondrial respiration abolished AdipoRon-induced Pdgfb increase in photoreceptors. Photoreceptor knockdown of Pdgfb delayed retinal vascular formation. Stimulation of the APN pathway might prevent hyperglycemia-associated retinal abnormalities and suppress phase I ROP in premature infants.},
	issn = {1757-4684},
	doi = {10.15252/emmm.201707966},
	author = {Fu, Zhongjie and L{\"o}fqvist, Chatarina A and Liegl, Raffael and Wang, Zhongxiao and Sun, Ye and Gong, Yan and Liu, Chi-Hsiu and Meng, Steven S and Burnim, Samuel B and Arellano, Ivana and Chouinard, My T and Duran, Rubi and Poblete, Alexander and Cho, Steve S and Akula, James D and Kinter, Michael and Ley, David and Hansen Pupp, Ingrid and Talukdar, Saswata and Hellstr{\"o}m, Ann and Smith, Lois E H}
}
