@article {1287971, title = {Difluprednate 0.05\% versus Prednisolone Acetate 1\% for Endogenous Anterior Uveitis: Pooled Efficacy Analysis of Two Phase 3 Studies}, journal = {Ocul Immunol Inflamm}, year = {2017}, month = {2017 Dec 20}, pages = {1-13}, abstract = {PURPOSE: To analyse pooled data from 2 similar phase 3 noninferiority studies comparing difluprednate 0.05\% versus prednisolone acetate 1\% in patients with endogenous anterior uveitis. METHODS: Patients received difluprednate alternating with vehicle or prednisolone acetate for 14\ days (8 drops/day in both groups), followed by tapering from day 14 to 28. All patients were observed until day 42. RESULTS: More patients on difluprednate than on prednisolone acetate were cleared of anterior chamber cells on day twenty one (71.3\% vs 54.7\%; p\ =\ 0.02); results were similar at the other time points. Treatment withdrawals were higher with prednisolone acetate than difluprednate (19.8\% vs 7.4\%; log-rank p\ =\ 0.02). Study discontinuation due to lack of efficacy was also higher with prednisolone acetate than difluprednate (14.0\% vs 0\%; p\ =\ 0.0002 [pre-specified exploratory analysis]). CONCLUSIONS: More difluprednate-treated eyes were quiet following 21\ days of treatment, and difluprednate-treated patients were much less likely to be withdrawn from the study because of treatment failure.}, issn = {1744-5078}, doi = {10.1080/09273948.2017.1407433}, author = {Sheppard, John D and Foster, C Stephen and Toyos, Melissa M and Markwardt, Kerry and Da Vanzo, Robert and Flynn, Thomas E and Kempen, John H} }