@article {1295869,
	title = {Impact of Forward and Backward Scattering and Corneal Higher-Order Aberrations on Visual Acuity after Penetrating Keratoplasty},
	journal = {Semin Ophthalmol},
	year = {2018},
	month = {2018 Jan 16},
	pages = {1-9},
	abstract = {PURPOSE: To assess the relationship of forward and backward scattering and corneal higher-order aberrations (HOAs) with corrected distance visual acuity (CDVA) after penetrating keratoplasty (PK). METHODS: This retrospective study comprised 25 eyes of 25 consecutive patients who underwent PK using the VisuMax femtosecond laser system and age-matched 25 eyes of 25 healthy subjects. We quantitatively assessed objective scattering index (OSI) using the double-pass instrument (OQAS II, Visiometrics), corneal densitometry (CD) and corneal HOAs with the Scheimpflug rotating camera (Pentacam HR, Oculus) 1\&nbsp;year postoperatively. RESULTS: The OSI, CD, and corneal HOAs were significantly larger in the PK group than those in the control group (p\&nbsp;<=\&nbsp;0.011). We found significant correlations of logMAR CDVA with the OSI (r\&nbsp;=\&nbsp;0.477, p\&nbsp;=\&nbsp;0.016), and with the anterior, posterior, and total corneal HOAs of the central 4-mm zone (anterior: r\&nbsp;=\&nbsp;0.573, p\&nbsp;=\&nbsp;0.003, posterior: r\&nbsp;=\&nbsp;0.596, p\&nbsp;=\&nbsp;0.002, total: r\&nbsp;=\&nbsp;0.472, p\&nbsp;=\&nbsp;0.017), but no significant association with the CD of the 0-2\&nbsp;mm zone at any layers (anterior: r\&nbsp;=\&nbsp;0.236, p\&nbsp;=\&nbsp;0.257, center: r\&nbsp;=\&nbsp;0.139, p\&nbsp;=\&nbsp;0.506, posterior: r\&nbsp;=\&nbsp;0.073, p\&nbsp;=\&nbsp;0.728, total: r\&nbsp;=\&nbsp;0.212, p\&nbsp;=\&nbsp;0.308). Similar results were obtained when the analysis was repeated with corneal HOAs of the central 6-mm zone and CDs in 2-6\&nbsp;mm zone. CONCLUSIONS: Our pilot study demonstrated that the postoperative CDVA was significantly correlated with OSI and corneal HOAs, but not with backward scattering in post-PK eyes, suggesting that OSI as well as corneal HOAs plays an essential role in postoperative visual performance after PK.},
	issn = {1744-5205},
	doi = {10.1080/08820538.2018.1427767},
	author = {Kobashi, Hidenaga and Kamiya, Kazutaka and Shimizu, Kimiya}
}
