@article {1319484,
	title = {Scotopic Microperimetric Assessment of Rod Function in Stargardt Disease (SMART) Study: Design and Baseline Characteristics (Report No. 1)},
	journal = {Ophthalmic Res},
	volume = {61},
	number = {1},
	year = {2019},
	month = {2019},
	pages = {36-43},
	abstract = {PURPOSE: To describe the study design and characteristics at first visit of participants in the longitudinal Scotopic Microperimetric Assessment of Rod Function in Stargardt Disease (SMART) study. METHODS: Scotopic microperimetry (sMP) was performed in one designated study eye in a subset of participants with molecularly proven ABCA4-associated Stargardt disease (STGD1) enrolled in a multicenter natural history study (ProgStar). Study visits were every 6 months over a period ranging from 6 to 24 months, and also included fundus autofluorescence (FAF). RESULTS: SMART enrolled 118 participants (118 eyes). At the first visit of SMART, the mean sensitivity in mesopic microperimetry was 11.48 ({\textpm}5.05; range 0.00-19.88) dB and in sMP 11.25 ({\textpm}5.26; 0-19.25) dB. For FAF, all eyes had a lesion of decreased autofluorescence (mean lesion size 3.62 [{\textpm}3.48; 0.10-21.46] mm2), and a total of 76 eyes (65.5\%) had a lesion of definitely decreased autofluorescence with a mean lesion size of 3.46 ({\textpm}3.60; 0.21-21.46) mm2. CONCLUSIONS: Rod function is impaired in STGD1 and can be assessed by sMP. Testing rod function may serve as a potential outcome measure for future clinical treatment trials. This is evaluated in the SMART study.},
	issn = {1423-0259},
	doi = {10.1159/000488711},
	author = {Strauss, Rupert W and Kong, Xiangrong and Bittencourt, Millena G and Ho, Alexander and Jha, Anamika and Sch{\"o}nbach, Etienne M and Ahmed, Mohamed I and Mu{\~n}oz, Beatriz and Ervin, Ann-Margret and Michaelides, Michel and Birch, David G and Sahel, Jos{\'e}-Alain and Sunness, Janet S and Zrenner, Eberhart and Bagheri, Saghar and Ip, Michael and Sadda, SriniVas and West, Sheila and Scholl, Hendrik P N and for~the~SMART~Study~Group}
}
