@article {1323921,
	title = {A Cross-Sectional Observational Study of Nailfold Capillary Morphology in Uveitis},
	journal = {Curr Eye Res},
	volume = {43},
	number = {11},
	year = {2018},
	month = {2018 Nov},
	pages = {1342-1350},
	abstract = {PURPOSE: We performed nailfold capillary microscopy to explore microvasculature abnormalities in uveitis overall and uveitis stratified in various ways. METHODS: This was a cross-sectional, case-control, observational study. One hundred and seven uveitis patients and 130 control subjects were included. We used a JH-1004 capillaroscope to perform nailfold capillary video microscopy on the fourth and fifth digits of each subject{\textquoteright}s nondominant hand. Videos were evaluated for hemorrhages, dilated capillary loops \&gt;\&nbsp;25\&nbsp;{\textmu}m, and avascular zones \&gt;\&nbsp;200\&nbsp;{\textmu}m. Univariate analyses were used for the assessment of case-control morphological differences and multivariate analyses were performed to assess the relation between nailfold capillaroscopic findings and uveitis subgroups. RESULTS: In univariate analysis, uveitis patients were more likely to have higher tortuosity ratings and reduced capillary density compared to controls (p\&nbsp;\&lt;\&nbsp;0.001 for both); furthermore, dilated capillary loops, avascular zone and hemorrhages were more frequent in uveitis versus control subjects (p\&nbsp;\&lt;\&nbsp;0.001 for all). Among cases, every unit increase in capillary density (vessels/mm) was associated with active uveitis (n\&nbsp;=\&nbsp;72 cases) versus inactive disease (n\&nbsp;=\&nbsp;35 cases; odds ratio (OR)\&nbsp;=\&nbsp;1.7; (95\% confidence interval (CI), 1.2-2.5) in multivariate analysis. Furthermore, the presence of any nailfold hemorrhage versus the absence of hemorrhage was more likely to be associated with posterior and panuveitis (n\&nbsp;=\&nbsp;41 cases combined) compared to anterior and intermediate uveitis (n\&nbsp;=\&nbsp;66 cases combined; OR\&nbsp;=\&nbsp;5.8; 95\% CI, 2.3-14.2). Moreover, we found a positive correlation between peripheral retinal leakage and nailfold capillaries dilation (r\&nbsp;=\&nbsp;0.33; p\&nbsp;=\&nbsp;0.015) that was not strictly significant based on the number of comparisons made. CONCLUSIONS: Our study provides support for non-ocular capillary bed abnormalities in uveitis, with interesting correlations based on disease stage and anatomical classification.},
	issn = {1460-2202},
	doi = {10.1080/02713683.2018.1496265},
	author = {Chen, Xuling and Yao, Xuyang and Chi, Ying and Guo, Chunying and Zhang, Jing and Li, Jun and Zhang, Shijie and Rong, Xin and Pasquale, Louis R and Yang, Liu}
}
