@article {1328877,
	title = {Commensal microflora-induced T cell responses mediate progressive neurodegeneration in glaucoma},
	journal = {Nat Commun},
	volume = {9},
	number = {1},
	year = {2018},
	month = {2018 Aug 10},
	pages = {3209},
	abstract = {Glaucoma is the most prevalent neurodegenerative disease and a leading cause of blindness worldwide. The mechanisms causing glaucomatous neurodegeneration are not fully understood. Here we show, using mice deficient in T and/or B cells and adoptive cell transfer, that transient elevation of intraocular pressure (IOP) is sufficient to induce T-cell infiltration into the retina. This T-cell infiltration leads to a prolonged phase of retinal ganglion cell degeneration that persists after IOP returns to a normal level. Heat shock proteins (HSP) are identified as target antigens of T-cell responses in glaucomatous mice and human glaucoma patients. Furthermore, retina-infiltrating T cells cross-react with human and bacterial HSPs; mice raised in the absence of commensal microflora do not develop glaucomatous T-cell responses or the associated neurodegeneration. These results provide compelling evidence that glaucomatous neurodegeneration is mediated in part by T cells that are pre-sensitized by exposure to commensal microflora.},
	issn = {2041-1723},
	doi = {10.1038/s41467-018-05681-9},
	author = {Chen, Huihui and Cho, Kin-Sang and Vu, T H Khanh and Shen, Ching-Hung and Kaur, Mandeep and Chen, Guochun and Mathew, Rose and McHam, M Lisa and Fazelat, Ahad and Lashkari, Kameran and Au, Ngan Pan Bennett and Tse, Joyce Ka Yu and Li, Yingqian and Yu, Honghua and Yang, Lanbo and Stein-Streilein, Joan and Ma, Chi Him Eddie and Woolf, Clifford J and Whary, Mark T and Jager, Martine J and Fox, James G and Chen, Jianzhu and Chen, Dong F}
}
