@article {1328892,
	title = {Neuronal-Specific TUBB3 Is Not Required for Normal Neuronal Function but Is Essential for Timely Axon Regeneration},
	journal = {Cell Rep},
	volume = {24},
	number = {7},
	year = {2018},
	month = {2018 Aug 14},
	pages = {1865-1879.e9},
	abstract = {We generated a knockout mouse for the neuronal-specific β-tubulin isoform Tubb3 to investigate its role in nervous system formation and maintenance. Tubb3 mice have no detectable neurobehavioral or neuropathological deficits, and upregulation of mRNA and protein of the remaining β-tubulin isotypes results in equivalent total β-tubulin levels in Tubb3 and wild-type mice. Despite similar levels of total β-tubulin, adult dorsal root ganglia lacking TUBB3 have decreased growth cone microtubule dynamics and a decreased neurite outgrowth rate of 22\% in\&nbsp;vitro and in\&nbsp;vivo. The effect of the 22\% slower growth rate is exacerbated for sensory recovery, where fibers must reinnervate the full volume of the skin to recover touch function. Overall, these data reveal that, while TUBB3 is not required for formation of the nervous system, it has a specific role in the rate of peripheral axon regeneration that cannot be replaced by other β-tubulins.},
	issn = {2211-1247},
	doi = {10.1016/j.celrep.2018.07.029},
	author = {Latremoliere, Alban and Cheng, Long and DeLisle, Michelle and Wu, Chen and Chew, Sheena and Hutchinson, Elizabeth B and Sheridan, Andrew and Alexandre, Chloe and Latremoliere, Frederic and Sheu, Shu-Hsien and Golidy, Sara and Omura, Takao and Huebner, Eric A and Fan, Yanjie and Whitman, Mary C and Nguyen, Elaine and Hermawan, Crystal and Pierpaoli, Carlo and Tischfield, Max A and Woolf, Clifford J and Engle, Elizabeth C}
}
