@article {1333849, title = {Atypical Perinuclear Anti-Neutrophil Cytoplasmic Antibodies in Ocular Inflammatory Diseases}, journal = {Ocul Immunol Inflamm}, year = {2018}, month = {2018 Sep 19}, pages = {1-5}, abstract = {PURPOSE: To characterize the clinical features of patients with ocular inflammatory diseases (OID) who tested positive for atypical perinuclear anti-neutrophil cytoplasmic antibodies (P-ANCA). METHODS: Retrospective case series of patients with OID seen at the Massachusetts Eye Research and Surgery Institute (MERSI) from April 2014 to April 2016. RESULTS: 813 patients were tested for ANCA with 34 patients (4\%) being positive for atypical P-ANCA. Among those with positive atypical P-ANCA, the most frequent diagnoses were anterior uveitis in 62\% (n\ =\ 21) followed by scleritis in 20\% (n\ =\ 7). Only one patient had an episode of recurrent disease flare-up. All but one patient, who had concomitant C-ANCA seropositivity and granulomatosis with polyangiitis, had a favorable disease course with controlled inflammation using topical and/or systemic immunomodulatory therapy. CONCLUSION: In contrast to typical C-ANCA and P-ANCA, atypical P-ANCA seropositivity was not associated with severe vasculitis or poor prognosis in patients with the OID.}, issn = {1744-5078}, doi = {10.1080/09273948.2018.1502787}, author = {Ebrahimiadib, Nazanin and Ma, Lina and Modjtahedi, Bobeck S and Davoudi, Samaneh and Rahmani, Safa and Syeda, Sarah and Stephenson, Andrew and Foster, Charles Stephen} }