@article {1351135,
	title = {Factors predictive of remission of new-onset anterior uveitis},
	journal = {Ophthalmology},
	volume = {121},
	number = {3},
	year = {2014},
	month = {2014 Mar},
	pages = {778-84},
	abstract = {PURPOSE: To identify factors predictive of remission of inflammation in new-onset anterior uveitis cases treated at tertiary uveitis care facilities.

DESIGN: Retrospective cohort study.

PARTICIPANTS: Patients seeking treatment at participating academic uveitis clinics within 90 days of initial diagnosis of anterior uveitis.

METHODS: Retrospective cohort study based on standardized chart review.

MAIN OUTCOME MEASURES: Factors predictive of remission (no disease activity without corticosteroid or immunosuppressive treatments at all visits during a 90-day period).

RESULTS: Nine hundred ninety eyes (687 patients) had a first-ever diagnosis of anterior uveitis within 90 days before initial presentation and had follow-up visits thereafter. The median follow-up time was 160 days. Systemic diagnoses with juvenile idiopathic arthritis (JIA; adjusted hazard ratio [aHR], 0.38; 95\% confidence interval [CI], 0.19-0.74) and Beh{\c c}et{\textquoteright}s disease (aHR, 0.10; 95\% CI, 0.01-0.85) were associated with a lower incidence of uveitis remission. Cases of bilateral uveitis (aHR, 0.68; 95\% CI, 0.54-0.87) and those with a history of cataract surgery before presentation (aHR, 0.51; 95\% CI, 0.29-0.87) also had a lower incidence of remission. Regarding clinical findings at the initial visit, a high degree of vitreous cells at initial presentation was associated with a lower incidence of remission (for 1+ or more vs. none: aHR, 0.72; 95\% CI, 0.55-0.95). An initial visual acuity of 20/200 or worse, with respect to 20/40 or better, also was predictive of a lower incidence of remission (aHR, 0.52; 95\% CI, 0.32-0.86).

CONCLUSIONS: Factors associated with a lower incidence of remission among new-onset anterior uveitis cases included diagnosis with JIA, Beh{\c c}et{\textquoteright}s disease, bilateral uveitis, history of cataract surgery, findings of 1+ or more vitreous cells at presentation, and an initial visual acuity of 20/200 or worse. Patients with these risk factors seem to be at higher risk of persistent inflammation; reciprocally, patients lacking these factors would be more likely to experience remission. Patients with risk factors for nonremission of uveitis should be managed taking into account the higher probability of a chronic inflammatory course.},
	keywords = {Adult, Arthritis, Juvenile, Behcet Syndrome, Cataract Extraction, Cohort Studies, Disease-Free Survival, Female, Follow-Up Studies, Humans, Male, Middle Aged, Remission, Spontaneous, Retrospective Studies, Risk Factors, Uveitis, Anterior, Visual Acuity, Vitreous Body},
	issn = {1549-4713},
	doi = {10.1016/j.ophtha.2013.09.041},
	author = {Artornsombudh, Pichaporn and Pistilli, Maxwell and Foster, C Stephen and Pujari, Siddharth S and Gangaputra, Sapna S and Jabs, Douglas A and Levy-Clarke, Grace A and Nussenblatt, Robert B and Rosenbaum, James T and Suhler, Eric B and Thorne, Jennifer E and Kempen, John H}
}
