@article {1351167,
	title = {Mammalian STE20-like kinase 2, not kinase 1, mediates photoreceptor cell death during retinal detachment},
	journal = {Cell Death Dis},
	volume = {5},
	year = {2014},
	month = {2014 May 29},
	pages = {e1269},
	abstract = {Photoreceptor cell death is the definitive cause of vision loss in retinal detachment (RD). Mammalian STE20-like kinase (MST) is a master regulator of both cell death and proliferation and a critical factor in development and tumorigenesis. However, to date the role of MST in neurodegeneration has not been fully explored. Utilizing MST1(-/-) and MST2(-/-) mice we identified MST2, but not MST1, as a regulator of photoreceptor cell death in a mouse model of RD. MST2(-/-) mice demonstrated significantly decreased photoreceptor cell death and outer nuclear layer (ONL) thinning after RD. Additionally, caspase-3 activation was attenuated in MST2(-/-) mice compared to control mice after RD. The transcription of p53 upregulated modulator of apoptosis (PUMA) and Fas was also reduced in MST2(-/-) mice post-RD. Retinas of MST2(-/-) mice displayed suppressed nuclear relocalization of phosphorylated YAP after RD. Consistent with the reduction of photoreceptor cell death, MST2(-/-) mice showed decreased levels of proinflammatory cytokines such as monocyte chemoattractant protein 1 and interleukin 6 as well as attenuated inflammatory CD11b cell infiltration during the early phase of RD. These results identify MST2, not MST1, as a critical regulator of caspase-mediated photoreceptor cell death in the detached retina and indicate its potential as a future neuroprotection target.},
	keywords = {Animals, Apoptosis, Caspase 3, Mice, Mice, Knockout, Photoreceptor Cells, Vertebrate, Protein-Serine-Threonine Kinases, Retinal Detachment, Tumor Suppressor Protein p53},
	issn = {2041-4889},
	doi = {10.1038/cddis.2014.218},
	author = {Matsumoto, H and Murakami, Y and Kataoka, K and Lin, H and Connor, K M and Miller, J W and Zhou, D and Avruch, J and Vavvas, D G}
}
