@article {1363127,
	title = {Biopsy of an anterior episcleral nodule as an aid in managing a ciliary body melanocytic tumor},
	journal = {Cornea},
	volume = {32},
	number = {8},
	year = {2013},
	month = {2013 Aug},
	pages = {1174-7},
	abstract = {PURPOSE: To demonstrate the value of a diagnostic biopsy of a fixed episcleral nodule overlying a uveal mass. METHOD: Clinicopathologic report with immunohistochemical investigations. RESULTS: B-scan ultrasonographic biomicroscopy disclosed in a 67-year-old man an asymptomatic placoid ciliary body tumor measuring 1.28 mm in thickness underlying a poorly pigmented, fixed episcleral nodule 0.56 mm in thickness. Biopsy of the episcleral nodule displayed benign nevus-type spindle cells with small nuclei, punctate nucleoli, no mitoses, and scattered melanophages. Immunohistochemistry demonstrated that the tumor cells were Ki67 negative (proliferation index, 0) and MART-1, HMB-45, and microphthalmia-associated transcription factor positive, all melanocytic markers. The melanophages but not the tumor cells were CD68 positive, a histiocytic marker. CONCLUSIONS: The results from biopsying an episcleral nodule can help to select among therapeutic options in managing an associated ciliary body tumor. A 1-year follow-up study and 3 sequential ultrasonographic studies in the current patient have failed to document the growth of the intraocular tumor, further confirming that it is a nevus. The excised epibulbar tumor has not recurred.},
	keywords = {Aged, Biopsy, Ciliary Body, Humans, Male, Melanoma, Uveal Neoplasms},
	issn = {1536-4798},
	doi = {10.1097/ICO.0b013e31829131f8},
	author = {Jakobiec, Frederick A and Gragoudas, Evangelos S and Colby, Kathryn A}
}
