@article {1363142,
	title = {Resolvin D1 and aspirin-triggered resolvin D1 regulate histamine-stimulated conjunctival goblet cell secretion},
	journal = {Mucosal Immunol},
	volume = {6},
	number = {6},
	year = {2013},
	month = {2013 Nov},
	pages = {1119-30},
	abstract = {Resolution of inflammation is an active process mediated by pro-resolution lipid mediators. As resolvin (Rv) D1 is produced in the cornea, pro-resolution mediators could be effective in regulating inflammatory responses to histamine in allergic conjunctivitis. Two key mediators of resolution are the D-series resolvins RvD1 or aspirin-triggered RvD1 (AT-RvD1). We used cultured conjunctival goblet cells to determine whether histamine actions can be terminated during allergic responses. We found cross-talk between two types of G protein-coupled receptors (GPRs), as RvD1 interacts with its receptor GPR32 to block histamine-stimulated H1 receptor increases in intracellular [Ca(2+)] ([Ca(2+)]i) preventing H1 receptor-mediated responses. In human and rat conjunctival goblet cells, RvD1 and AT-RvD1 each block histamine-stimulated secretion by preventing its increase in [Ca(2+)]i and activation of extracellular regulated-protein kinase (ERK)1/2. We suggest that D-series resolvins regulate histamine responses in the eye and offer new treatment approaches for allergic conjunctivitis or other histamine-dependent pathologies.},
	keywords = {Animals, Aspirin, Bodily Secretions, Calcium Signaling, Cells, Cultured, Conjunctivitis, Allergic, Docosahexaenoic Acids, Extracellular Signal-Regulated MAP Kinases, Goblet Cells, Histamine, Histamine H1 Antagonists, Humans, Male, Rats, Rats, Sprague-Dawley, Receptor Cross-Talk, Receptors, G-Protein-Coupled, Receptors, Histamine H1},
	issn = {1935-3456},
	doi = {10.1038/mi.2013.7},
	author = {Li, D and Hodges, R R and Jiao, J and Carozza, R B and Shatos, M A and Chiang, N and Serhan, C N and Dartt, D A}
}
