@article {1363193,
	title = {Molecular evolution of human adenoviruses},
	journal = {Sci Rep},
	volume = {3},
	year = {2013},
	month = {2013},
	pages = {1812},
	abstract = {The recent emergence of highly virulent human adenoviruses (HAdVs) with new tissue tropisms underscores the need to determine their ontogeny. Here we report complete high quality genome sequences and analyses for all the previously unsequenced HAdV serotypes (n = 20) within HAdV species D. Analysis of nucleotide sequence variability for these in conjunction with another 40 HAdV prototypes, comprising all seven HAdV species, confirmed the uniquely hypervariable regions within species. The mutation rate among HAdV-Ds was low when compared to other HAdV species. Homologous recombination was identified in at least two of five examined hypervariable regions for every virus, suggesting the evolution of HAdV-Ds has been highly dependent on homologous recombination. Patterns of alternating GC and AT rich motifs correlated well with hypervariable region recombination sites across the HAdV-D genomes, suggesting foci of DNA instability lead to formulaic patterns of homologous recombination and confer agility to adenovirus evolution.},
	keywords = {Adenovirus Infections, Human, Adenoviruses, Human, DNA, Viral, Evolution, Molecular, Genome, Viral, Humans, Phylogeny, Recombination, Genetic, Sequence Analysis, DNA},
	issn = {2045-2322},
	doi = {10.1038/srep01812},
	author = {Robinson, Christopher M and Singh, Gurdeep and Lee, Jeong Yoon and Dehghan, Shoaleh and Rajaiya, Jaya and Liu, Elizabeth B and Yousuf, Mohammad A and Betensky, Rebecca A and Jones, Morris S and Dyer, David W and Seto, Donald and Chodosh, James}
}
