@article {1363244, title = {Risk of choroidal neovascularization among the uveitides}, journal = {Am J Ophthalmol}, volume = {156}, number = {3}, year = {2013}, month = {2013 Sep}, pages = {468-477.e2}, abstract = {PURPOSE: To evaluate the risk, risk factors, and visual impact of choroidal neovascularization (CNV) in uveitis cases. DESIGN: Retrospective cohort study. METHODS: Standardized medical record review at 5 tertiary centers. RESULTS: Among 15,137 uveitic eyes (8868 patients), CNV was rare in the cases of anterior or intermediate uveitis. Among the 4041 eyes (2307 patients) with posterior uveitis or panuveitis, 81 (2.0\%) had CNV at presentation. Risk factors included posterior uveitis in general and specific uveitis syndromes affecting the outer retina-retinal pigment epithelium-choroid interface. Among the 2364 eyes (1357 patients) with posterior uveitis or panuveitis and free of CNV at the time of cohort entry, the cumulative 2-year incidence of CNV was 2.7\% (95\% confidence interval [CI], 1.8\% to 3.5\%). Risk factors for incident CNV included currently active inflammation (adjusted hazard ratio [aHR], 2.13; 95\% CI, 1.26 to 3.60), preretinal neovascularization (aHR, 3.19; 95\% CI, 1.30 to 7.80), and prior diagnosis of CNV in the contralateral eye (aHR, 5.79; 95\% CI, 2.77 to 12.09). Among specific syndromes, the incidence was greater in Vogt-Koyanagi-Harada syndrome (aHR, 3.37; 95\% CI, 1.52 to 7.46) and punctate inner choroiditis (aHR, 8.67; 95\% CI, 2.83 to 26.54). Incident CNV was associated with a 2-line loss of visual acuity (+0.19 logarithm of the minimal angle of resolution units; 95\% CI, 0.079 to 0.29) from the preceding visit. CONCLUSIONS: CNV is an uncommon complication of uveitis associated with visual impairment that occurs more commonly in forms affecting the outer retina-retinal pigment epithelium-choroid interface, during periods of inflammatory activity, in association with preretinal neovascularization, and in second eyes of patients with unilateral CNV. Because CNV is treatable, a systematic approach to early detection in high-risk patients may be appropriate.}, keywords = {Adult, Choroidal Neovascularization, Female, Humans, Incidence, Male, Odds Ratio, Prevalence, Retrospective Studies, Risk Assessment, Risk Factors, United States, Uveitis, Vision Disorders, Visual Acuity}, issn = {1879-1891}, doi = {10.1016/j.ajo.2013.04.040}, author = {Baxter, Sally L and Pistilli, Maxwell and Pujari, Siddharth S and Liesegang, Teresa L and Suhler, Eric B and Thorne, Jennifer E and Foster, C Stephen and Jabs, Douglas A and Levy-Clarke, Grace A and Nussenblatt, Robert B and Rosenbaum, James T and Kempen, John H} }