@article {1363278,
	title = {Effects of dorzolamide-timolol and brimonidine-timolol on retinal vascular autoregulation and ocular perfusion pressure in primary open angle glaucoma},
	journal = {J Ocul Pharmacol Ther},
	volume = {29},
	number = {7},
	year = {2013},
	month = {2013 Sep},
	pages = {639-45},
	abstract = {PURPOSE: To assess whether dorzolamide 2\%-timolol 0.5\% (D/T) and/or brimonidine 0.2\%-timolol 0.5\% (B/T) alters retinal vascular autoregulation (RVA) and seated ocular perfusion pressure (sOPP) in primary open angle glaucoma (POAG) patients who demonstrate retinal vascular dysregulation (RVD) on timolol 0.5\% alone. METHODS: In this prospective, observer-masked, crossover study, 21 POAG patients with untreated intraocular pressure (IOP) \&gt;21 mmHg were treated for 6 weeks with timolol 0.5\%. Subsequently, we measured inferior temporal retinal artery blood flow in the left eye with subjects seated and then while reclined for 30 min using the Canon Laser Blood Flowmeter. Subjects with a change in retinal blood flow in response to posture change outside of the range previously found in healthy subjects were designated as having RVD and randomized to either D/T or B/T for 6 weeks and re-tested. This was followed by treatment with the opposite medication. RESULTS: Seven of the 21 subjects demonstrated RVD in response to posture change following timolol 0.5\%. Multiple linear regression analysis indicated that lower sOPP was the main determinant of RVD (P=0.033). After treatment with D/T, all 7 converted from RVD to normal RVA status (P=0.001). Four of 6 subjects showed a similar return to normal RVA following B/T (P=0.066). Mid-morning sOPP was 41.1{\textpm}5.5 mmHg post-timolol, 46.3{\textpm}6.5 mmHg post-D/T, and 38.6{\textpm}6.0 mmHg post-B/T (D/T vs. B/T, P=0.026). CONCLUSIONS: D/T significantly improved RVA in POAG patients exhibiting RVD while on timolol 0.5\% alone. D/T also increased sOPP compared to B/T. There was no significant difference (P=0.37) between D/T and B/T in improving RVA.},
	keywords = {Adult, Aged, Aged, 80 and over, Antihypertensive Agents, Brimonidine Tartrate, Cross-Over Studies, Drug Combinations, Eye, Female, Glaucoma, Open-Angle, Homeostasis, Humans, Intraocular Pressure, Male, Middle Aged, Prospective Studies, Quinoxalines, Regional Blood Flow, Sulfonamides, Thiophenes, Timolol},
	issn = {1557-7732},
	doi = {10.1089/jop.2012.0271},
	author = {Feke, Gilbert T and Rhee, Douglas J and Turalba, Angela V and Pasquale, Louis R}
}
