@article {1364522,
	title = {Comparative genomics of enterococci: variation in Enterococcus faecalis, clade structure in E. faecium, and defining characteristics of E. gallinarum and E. casseliflavus},
	journal = {MBio},
	volume = {3},
	number = {1},
	year = {2012},
	month = {2012},
	pages = {e00318-11},
	abstract = {The enterococci are Gram-positive lactic acid bacteria that inhabit the gastrointestinal tracts of diverse hosts. However, Enterococcus faecium and E. faecalis have emerged as leading causes of multidrug-resistant hospital-acquired infections. The mechanism by which a well-adapted commensal evolved into a hospital pathogen is poorly understood. In this study, we examined high-quality draft genome data for evidence of key events in the evolution of the leading causes of enterococcal infections, including E. faecalis, E. faecium, E. casseliflavus, and E. gallinarum. We characterized two clades within what is currently classified as E. faecium and identified traits characteristic of each, including variation in operons for cell wall carbohydrate and putative capsule biosynthesis. We examined the extent of recombination between the two E. faecium clades and identified two strains with mosaic genomes. We determined the underlying genetics for the defining characteristics of the motile enterococci E. casseliflavus and E. gallinarum. Further, we identified species-specific traits that could be used to advance the detection of medically relevant enterococci and their identification to the species level.},
	keywords = {Alleles, Bacterial Proteins, Cell Wall, Enterococcus, Evolution, Molecular, Genetic Loci, Genetic Variation, Genome, Bacterial, Gram-Positive Bacterial Infections, Host-Pathogen Interactions, Phylogeny, Polysaccharides, Bacterial, Species Specificity},
	issn = {2150-7511},
	doi = {10.1128/mBio.00318-11},
	author = {Palmer, Kelli L and Godfrey, Paul and Griggs, Allison and Kos, Veronica N and Zucker, Jeremy and Desjardins, Christopher and Cerqueira, Gustavo and Gevers, Dirk and Walker, Suzanne and Wortman, Jennifer and Feldgarden, Michael and Haas, Brian and Birren, Bruce and Gilmore, Michael S}
}
