@article {1364558,
	title = {Predictability of intraocular lens calculation and early refractive status: the Infant Aphakia Treatment Study},
	journal = {Arch Ophthalmol},
	volume = {130},
	number = {3},
	year = {2012},
	month = {2012 Mar},
	pages = {293-9},
	abstract = {OBJECTIVE: To report the accuracy of intraocular lens (IOL) power calculations and the early refractive status in pseudophakic eyes of infants in the Infant Aphakia Treatment Study. METHODS: Eyes randomized to receive primary IOL implantation were targeted for a postoperative refraction of +8.0 diopters (D) for infants 28 to 48 days old at surgery and +6.0 D for those 49 days or older to younger than 7 months at surgery using the Holladay 1 formula. Refraction 1 month after surgery was converted to spherical equivalent, and prediction error (PE; defined as the calculated refraction minus the actual refraction) and absolute PE were calculated. Baseline eye and surgery characteristics and A-scan quality were analyzed to compare their effect on PE. MAIN OUTCOME MEASURES: Prediction error. RESULTS: Fifty-six eyes underwent primary IOL implantation; 7 were excluded for lack of postoperative refraction (n = 5) or incorrect technique in refraction (n = 1) or biometry (n = 1). Overall mean (SD) absolute PE was 1.8 (1.3) D and mean (SD) PE was +1.0 (2.0) D. Absolute PE was less than 1 D in 41\% of eyes but greater than 2 D in 41\% of eyes. Mean IOL power implanted was 29.9 D (range, 11.5-40.0 D); most eyes (88\%) implanted with an IOL of 30.0 D or greater had less postoperative hyperopia than planned. Multivariate analysis revealed that only short axial length (\&lt;18 mm) was significant for higher PE. CONCLUSIONS: Short axial length correlates with higher PE after IOL placement in infants. Less hyperopia than anticipated occurs with axial lengths of less than 18 mm or high-power IOLs. Application to Clinical Practice Quality A-scans are essential and higher PE is common, with a tendency for less hyperopia than expected. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT00212134.},
	keywords = {Cataract, Cataract Extraction, Child, Preschool, Follow-Up Studies, Humans, Hyperopia, Infant, Lens Implantation, Intraocular, Lenses, Intraocular, Postoperative Complications, Predictive Value of Tests, Refractometry, Visual Acuity},
	issn = {1538-3601},
	doi = {10.1001/archophthalmol.2011.358},
	author = {VanderVeen, Deborah K and Nizam, Azhar and Lynn, Michael J and Bothun, Erick D and McClatchey, Scott K and Weakley, David R and DuBois, Lindreth G and Lambert, Scott R and Infant Aphakia Treatment Study Group}
}
