@article {1417552,
	title = {Generation of Tumor Antigen-Specific Cytotoxic T Lymphocytes from Pluripotent Stem Cells},
	journal = {Methods Mol Biol},
	volume = {1884},
	year = {2019},
	month = {2019},
	pages = {43-55},
	abstract = {Immunotherapy is a developing but very promising arsenal to treat cancer. Acquiring a more potent and effective approach in cancer immunotherapy is always the ultimate pursuance. CTL-based therapies are highly acclaimed recently due to its direct killing property. However, difficulty in obtaining adequate number of CTLs is still a major obstacle. In previous studies, it is shown that pluripotent stem cell-derived cytotoxic T lymphocytes (CTL)-especially the genetically engineered tumor antigen-specific CTLs-may serve as a good candidate for this goal. Here we introduce a novel approach in generating tumor antigen-specific CTLs from induced pluripotent stem cells (iPSCs) by using both in vitro and in vivo priming mechanisms for the tumor management in a murine melanoma model.},
	issn = {1940-6029},
	doi = {10.1007/978-1-4939-8885-3_3},
	author = {Chen, Xiaoniao and Lei, Fengyang and Wang, Liqiang and Xiong, Xiaofang and Song, Jianxun}
}
