@article {1417564,
	title = {Myeloid Sarcoma with Megakaryoblastic Differentiation Arising in the Conjunctiva},
	journal = {Ocul Oncol Pathol},
	volume = {5},
	number = {1},
	year = {2019},
	month = {2019 Jan},
	pages = {28-35},
	abstract = {An 87-year-old woman not known to have either a lymphoma or leukemia developed a left multinodular, fish-flesh superior epibulbar and forniceal mass. A biopsy disclosed a blastic tumor with scattered multinucleated immature megakaryoblasts. Immunophenotyping of bone marrow cells revealed strong positivity for CD7, CD31, CD43, CD45, CD61, and CD117; CD71, myeloperoxidase, and lysozyme were also positive in scattered cells. Forty percent of the neoplastic cells were Ki-67 positive. Cytogenetic studies indicated a trisomy 8 (associated with worse prognosis) and a t(12; 17) translocation. Desmin, smooth muscle actin, pancytokeratin, CAM 5.2, adipophilin, tryptase, S100, SOX10, MART1, and E-cadherin were negative, ruling out a nonhematopoietic tumor. The conjunctival lesion was diagnosed as a myeloid sarcoma with megakaryoblastic differentiation, a rare variant. It probably arose from a myelodysplastic syndrome. This is the first case of its type to develop in the conjunctiva.},
	issn = {2296-4681},
	doi = {10.1159/000488057},
	author = {Jakobiec, Frederick A and Wolkow, Natalie and Zakka, Fouad R and Rubin, Peter A D}
}
