@article {1424802,
	title = {Predictors of Primary Intracranial Hypertension in Children Using a Newly Suggested Opening Pressure Cutoff of 280 mm HO},
	journal = {Pediatr Neurol},
	volume = {91},
	year = {2019},
	month = {2019 Feb},
	pages = {27-33},
	abstract = {OBJECTIVES: We assessed the clinical characteristics of primary intracranial hypertension (PIH) in children using a newly recommended threshold for cerebrospinal fluid opening pressure (280 mm HO). METHOD: Cross-sectional study of patients age <=21 years who had a lumbar puncture done for evaluation of PIH. Patients were excluded if lumbar puncture was done for a suspected infection, seizure, mental status changes, multiple sclerosis, or Guillain-Barre syndrome. Cases were identified using a text-search module followed by manual review. We performed χ2 analysis for categorical data and Mann-Whitney U test for continuous data, followed by a binary logistic regression. RESULTS: We identified 374 patients of whom 67\% were female, median age was 13 years interquartile range (11 to 16 years), and admission rate was 24\%. Using an opening pressure cutoff of 250 mm HO, 127 patients (34\%) were identified as having PIH, whereas using the new cutoff 105 patients (28\%) met PIH criteria. Predictors for PIH included optic disc edema or sixth nerve palsy using both old, odds ratio (OR) 7.6 (4.3, 13.5), and new cutoffs, OR 9.7 (95\% confidence interval 5.1, 18.5). Headache duration <=61 days is predictive of PIH using the new cutoff OR 4.1 (95\% confidence interval 1.3, 12.8). A model is presented which stratifies patients into groups with low (7\%), medium (18\%), and high (greater than 42\%) risk of PIH. CONCLUSIONS: A higher cerebrospinal fluid opening pressure threshold in the criteria of PIH is associated with PIH patients with a different symptom profile. Children with optic disc edema, bulging fontanel or sixth nerve palsy, are at increased risk for PIH.},
	issn = {1873-5150},
	doi = {10.1016/j.pediatrneurol.2018.09.013},
	author = {Delaney, Atima C and Velarde, Aynslee and Harper, Marvin B and Lebel, Alyssa and Landschaft, Assaf and Monuteaux, Michael and Heidary, Gena and Kimia, Amir A}
}
