@article {1435423,
	title = {Using Healthcare Databases to Refine Understanding of Exploratory Associations Between Drugs and Progression of Open-Angle Glaucoma},
	journal = {Clin Pharmacol Ther},
	volume = {106},
	number = {4},
	year = {2019},
	month = {2019 Oct},
	pages = {874-883},
	abstract = {We sought to refine understanding about associations identified in prior studies between angiotensin-II receptor blockers, metformin, selective serotonin reuptake inhibitors, fibric-acid derivatives, or calcium channel blockers and progression to glaucoma filtration surgery for open-angle glaucoma (OAG). We used new-initiator, active-comparator cohort designs to investigate these drugs in two data sources. We adjusted for confounders using stabilized inverse-probability-of-treatment weights and evaluated results using "intention-to-treat" and "as-treated" follow-up approaches. In both data sources, Kaplan-Meier curves showed trends for more rapid progression to glaucoma filtration surgery in patients taking calcium channel blockers compared with thiazides with as-treated (MarketScan P\&nbsp;=\&nbsp;0.15; Medicare P\&nbsp;=\&nbsp;0.03) and intention-to-treat follow-up (MarketScan P\&nbsp;\&lt;\&nbsp;0.01; Medicare P\&nbsp;=\&nbsp;0.10). There was suggestion of delayed progression for selective serotonin reuptake inhibitor compared with tricyclic antidepressants in Medicare, which was not observed in MarketScan. Our study provided support for a relationship between calcium channel blockers and OAG progression but not for other investigated drugs.},
	issn = {1532-6535},
	doi = {10.1002/cpt.1490},
	author = {Wang, Shirley V and Li, Ning and Rice, Dennis S and Grosskreutz, Cynthia L and Dryja, Thaddeus P and Prasanna, Ganesh and Lii, Joyce and Gagne, Joshua J}
}
