@article {1435426,
	title = {Evaluation of the Ocular Surface Disease Index Questionnaire as a Discriminative Test for Clinical Findings in Dry Eye Disease Patients},
	journal = {Curr Eye Res},
	volume = {44},
	number = {9},
	year = {2019},
	month = {2019 Sep},
	pages = {941-947},
	abstract = {: To investigate to what extent the OSDI can be utilized as a discriminative test for clinical findings. : One thousand and ninety patients with dry eye disease (DED) were consecutively included and examined for osmolarity, tear film break-up time (TFBUT), ocular protection index (OPI), ocular surface staining (OSS), Schirmer I test (ST), meibum expressibility (ME), meibum quality (MQ), and diagnosis of meibomian gland dysfunction (MGD). Receiver-operating characteristic curve (ROC) analysis considering optimum balanced sensitivity and specificity (close to 50\%) was used for assessment. : The present study on more than 1,000 patients indicates that the OSDI in the ROC curve analysis is a poor discriminator of pathological scores for TFBUT <= 5 (AUC = 0.553; = .012) and <=10 s (AUC = 0.608; = .002), OSS >= 3 (AUC = 0.54; = .043), ST <= 5 (AUC = 0.550; = .032) and <=10 mm/5 min (AUC = 0.544; = .016), and ME >= 1 (AUC = 0.594; = \&lt;0.001). Pathological scores for osmolarity \&gt;308 and \&gt;316 mOsm/L, OPI, OSS \&gt; 1, MQ, and MGD could not be discriminated by OSDI ( \&gt; .05). : Cut-off values for the OSDI can be defined to discriminate pathological TFBUT (<=5 and <=10), OSS (>=3), ST (<=5 and <=10) and ME, however, the discriminability was low. Our comprehensive study emphasises the importance of taking both symptoms and signs into account in DED management.},
	issn = {1460-2202},
	doi = {10.1080/02713683.2019.1604972},
	author = {Yazdani, Mazyar and Chen, Xiangjun and Tashbayev, Behzod and Utheim, {\O}ygunn A and R{\ae}der, Sten and Hua, Yanjun and Eidet, Jon R and Stojanovic, Aleksandar and Dartt, Darlene A. and Utheim, Tor P}
}
