@article {1445319,
	title = {Glaucoma Management in Patients with Aniridia and Boston Type 1 Keratoprosthesis},
	journal = {Am J Ophthalmol},
	year = {2019},
	month = {2019 Jun 24},
	abstract = {PURPOSE: To assess outcomes and glaucoma management in eyes with aniridia following Boston type 1 Keratoprosthesis (KPro) implantation. DESIGN: Retrospective, interventional comparative case series. METHODS: POPULATION: Patients with aniridia and patients with other preoperative diagnoses (excluding Stevens-Johnson syndrome, mucous membrane pemphigoid, and congenital disorders) who underwent KPro implantation at Massachusetts Eye and Ear with at least 2 years of follow-up. One eye per patient was selected based on the longer follow-up time. MAIN OUTCOME: Intermediate and long-term outcomes related to glaucoma. RESULTS: The aniridia (n=22) and comparison (n=61) groups had similar preoperative visual acuity (VA, mean {\textpm} standard deviation, 1.86{\textpm}0.52 LogMAR, p=0.33) and follow-up time (65.6{\textpm}26.3 months, p=0.25). Prior to KPro implantation, eyes with aniridia had more glaucoma (76.2\%) and glaucoma surgery (57.1\%) than comparison eyes (51.8\%, p=0.053; 23.2\%, p=0.005, respectively). More Ahmed valves were co-implanted with KPro in aniridia (47.6\%) versus comparison eyes (17.9\%, p=0.008). At final follow-up, more aniridia eyes had glaucoma (90.5\%) than comparison eyes (64.3\%, p=0.02), but the two groups had similar percentages of eyes with cup-to-disc ratio (CDR) \&gt;0.8 (23.8\% vs. 30.4\%, p=0.57) or CDR progression of >=0.2 (42.9\% vs. 44.6\%, p=0.89, respectively). None of the eyes with prophylactic tube implantation developed glaucoma. Eyes with and without aniridia did not differ in post-KPro VA improvement (72.7\%, 72.1\%, p=0.96), and final VA (1.28{\textpm}0.79 LogMAR, 1.23{\textpm}0.98 LogMAR, p=0.51). CONCLUSION: Despite a higher glaucoma prevalence, eyes with aniridia achieved similar VA as comparison eyes with more than 5 years of mean follow-up time. Boston KPro offers satisfactory visual rehabilitation in aniridia when glaucoma is managed aggressively.},
	issn = {1879-1891},
	doi = {10.1016/j.ajo.2019.06.018},
	author = {Silva, Rafaella Nascimento E and Shen, Lucy Q and Chiou, Carolina A and Shanbhag, Swapna S and Paschalis, Eleftherios I and Pasquale, Louis R and Colby, Kathryn A and Dohlman, Claes H and Chodosh, James and Alves, Milton R}
}
