@article {1452955,
	title = {Long-Term Effect of a Treatment Protocol for Acute Ocular Involvement in Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis},
	journal = {Am J Ophthalmol},
	volume = {208},
	year = {2019},
	month = {2019 Dec},
	pages = {331-341},
	abstract = {PURPOSE: To describe the long-term effect of a treatment protocol for ocular involvement in acute Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN), including focused ocular examination and pathology-appropriate use of lubrication, topical corticosteroids, topical antibiotics, and amniotic membrane transplantation (AMT). DESIGN: Retrospective, comparative case series. METHODS: A total of 48 patients (96 eyes) were included in this study. Nine of 48 patients (18 eyes) had acute SJS/TEN from 2000 to 2007 and did not receive protocol care (Group I). Thirty-nine of 48 patients (78 eyes) had acute SJS/TEN from 2008 to 2017 and received protocol care (Group II). The main outcome measures were best-corrected visual acuity (BCVA) at final follow-up visit and incidence of complications in the chronic phase. RESULTS: No eyes in Group I received AMT for SJS/TEN, compared to 87\% of qualifying eyes in Group II (P \&lt; .0001) There was a significant difference in the proportion of eyes with BCVA >=20/40 at last follow-up between Group I and Group II (33\% vs 92\%, P\&nbsp;\&lt;\&nbsp;.001). The proportion of eyes with vision-threatening complications in the chronic phase was significantly higher in Group I versus Group II (67\% vs 17\%, P\&nbsp;= .002), with most complications occurring in the first 2 years after disease onset in both groups. CONCLUSIONS: A specific protocol for acute ocular care in SJS/TEN, including aggressive use of AMT, was highly successful in reducing corneal blindness and severe vision-threatening complications of the disorder.},
	issn = {1879-1891},
	doi = {10.1016/j.ajo.2019.07.006},
	author = {Shanbhag, Swapna S and Rashad, Ramy and Chodosh, James and Saeed, Hajirah N}
}
