@article {1474197,
	title = {Elevated levels of IL-6 and IGFBP-1 predict low serum IGF-1 levels during continuous infusion of rhIGF-1/rhIGFBP-3 in extremely preterm infants},
	journal = {Growth Horm IGF Res},
	volume = {50},
	year = {2019},
	month = {2019 Nov 09},
	pages = {1-8},
	abstract = {OBJECTIVE: Steady state insulin-like growth factor-1 (IGF-1) levels vary significantly during continuous intravenous infusion of recombinant human insulin-like growth factor-1/recombinant human insulin-like growth factor binding protein-3 (rhIGF-1/rhIGFBP-3) in the first weeks of life in extremely preterm infants. We evaluated interleukin-6 (IL-6) and insulin-like growth factor binding protein-1 (IGFBP-1) levels as predictors of low IGF-1 levels. METHODS: Nineteen extremely preterm infants were enrolled in a trial, 9 received rhIGF-1/rhIGFBP-3 and 10 received standard neonatal care. Blood samples were analyzed daily for IGF-1, IL-6 and IGFBP-1 during intervention with rhIGF-1/rhIGFBP-3. RESULTS: Thirty seven percent of IGF-1 values during active treatment were \&lt;20 μg/L. Among treated infants, higher levels of IL-6, one and two days before sampled IGF-1, were associated with IGF-1 \&lt; 20 μg/L, gestational age adjusted OR 1.30 (95\% CI 1.03-1.63), p = .026, and 1.57 (95\% CI 1.26-1.97), p \&lt; .001 respectively. Higher levels of IGFBP-1 one day before sampled IGF-1 was also associated with IGF-1 \&lt; 20 μg/L, gestational age adjusted OR 1.74 (95\% CI 1.19-2.53), p = .004. CONCLUSION: In preterm infants receiving continuous infusion of rhIGF-1/rhIGFBP-3, higher levels of IL-6 and IGFBP-1 preceded lower levels of circulating IGF-1. These findings demonstrate a need to further evaluate if inflammation and/or infection suppress serum IGF-1 levels. The trial is registered at ClinicalTrials.gov (NCT01096784).},
	issn = {1532-2238},
	doi = {10.1016/j.ghir.2019.11.001},
	author = {Klevebro, Susanna and Hellgren, Gunnel and Hansen-Pupp, Ingrid and Wackernagel, Dirk and Hallberg, Boubou and Borg, Jan and Pivodic, Aldina and Smith, Lois and Ley, David and Hellstr{\"o}m, Ann}
}
