@article {1474198,
	title = {Iontophoretic Dexamethasone Phosphate Compared to Topical Prednisolone Acetate 1\% for Noninfectious Anterior Segment Uveitis},
	journal = {Am J Ophthalmol},
	year = {2019},
	month = {2019 Nov 11},
	abstract = {PURPOSE: To evaluate the safety and efficacy of dexamethasone phosphate ophthalmic solution (EGP-437) delivered by transscleral iontophoresis using the EyeGate{\textregistered} II Drug Delivery System, compared to topical prednisolone acetate 1\% (PA 1\%), in subjects with noninfectious anterior uveitis. DESIGN: Prospective, randomized, double-masked, parallel-group, non-inferiority clinical trial METHODS: A total of 193 subjects with active noninfectious anterior uveitis (anterior chamber [AC] cell count >=11 cells) were randomized to EGP-437 delivered via iontophoresis (Days 0 and 7) or self-administered PA 1\% daily (tapered schedule, Days 0-28). Masking was maintained with placebo iontophoresis/eyedrops. The primary efficacy endpoint was the proportion of subjects with an AC cell count of zero on Day 14; noninferiority of EGP-437 was defined if the lower limit of the confidence interval for the difference (EGP-437 minus PA 1\%) was less than -10\%. RESULTS: At Day 14, 32/96 (33.3\%) EGP-437 subjects and 32/97 (33.0\%) PA 1\% subjects had an AC cell count of zero (difference [95\% confidence interval], 0.34 [-12.94, 13.63]; P=0.064). Efficacy trended better with EGP-437 among patients with more severe baseline uveitis (AC cell count \&gt;25). Safety and tolerability were good with both treatments. EGP-437 subjects experienced fewer IOP elevations >=6 mm Hg versus PA 1\% subjects (13 vs 24 incidents through Day 28). CONCLUSIONS: Despite clinically similar response rates, statistical noninferiority of EGP-437 versus a tapered regimen of PA 1\% was not achieved. Numerical trends suggesting fewer IOP elevations with EGP-437, similar efficacy overall, and possibly better efficacy in more severe disease warrant further study.},
	issn = {1879-1891},
	doi = {10.1016/j.ajo.2019.10.032},
	author = {Sheppard, John and Garg, Sunir and Lievens, Christopher and Brandano, Lisa and Wirostko, Barbara and Korenfeld, Michael and Raizman, Michael and Foster, C Stephen}
}
