@article {1474200,
	title = {Design and Outcomes of a Novel Keratoprosthesis: Addressing Unmet Needs in End-Stage Cicatricial Corneal Blindness},
	journal = {Cornea},
	volume = {39},
	number = {4},
	year = {2020},
	month = {2020 Apr},
	pages = {484-490},
	abstract = {PURPOSE: The most commonly applied prosthetic devices for corneal blindness in the setting of severe cicatricial keratoconjunctivitis are the Boston keratoprosthesis type II and the modified osteo-odonto-keratoprosthesis, with these requiring either normal eyelid skin or a healthy cuspid tooth, respectively. For patients with neither attribute, we developed a new keratoprosthesis device combining positive aspects of both Boston keratoprosthesis type II and modified osteo-odonto-keratoprosthesis, which we have named the "Lux." METHODS: Short-term postoperative outcomes for the Lux keratoprosthesis, best-corrected visual acuity (BCVA), device retention, and complications, were examined in a retrospective case series of 9 eyes of 9 patients implanted at 4 centers. RESULTS: Seven of 9 (77.8\%) eyes had cicatricial corneal blindness due to autoimmune disease and 2 (22.2\%) from severe burns. Preoperative BCVA was <=hand motions in all patients. Three (33.3\%) had previously received at least 1 keratoprosthesis in the affected eye, and 4 (44.4\%) had previously undergone >=1 therapeutic keratoplasty. One patient had 19 previous eye surgeries. The mean duration of postoperative follow-up was 18.7 months (range 7-28 months). BCVA of >=20/200 was achieved in all 9 patients, with 2 (22.2\%) reaching 20/20 at the last examination, and all 9 (100\%) of the devices were retained. One recipient developed a retinal detachment 2 months after implantation. Two (22.2\%) patients required placement of a glaucoma drainage device. CONCLUSIONS: The Lux keratoprosthesis was developed for patients with severe cicatricial keratoconjunctivitis who were otherwise not candidates for existing keratoprosthesis designs. Short-term outcomes after implantation of the Lux keratoprosthesis were encouraging.},
	issn = {1536-4798},
	doi = {10.1097/ICO.0000000000002207},
	author = {Bakshi, Shaunak K and Graney, John and Paschalis, Eleftherios I and Agarwal, Shweta and Basu, Sayan and Iyer, Geetha and Liu, Christopher and Srinivasan, Bhaskar and Chodosh, James}
}
