@article {1504084,
	title = {Outcomes of Bilateral Cataracts Removed in Infants 1 to 7 Months of Age Using the Toddler Aphakia and Pseudophakia Treatment Study Registry},
	journal = {Ophthalmology},
	volume = {127},
	number = {4},
	year = {2020},
	month = {2020 Apr},
	pages = {501-510},
	abstract = {PURPOSE: To evaluate outcomes of bilateral cataract surgery in infants 1 to 7 months of age performed by Infant Aphakia Treatment Study (IATS) investigators during IATS recruitment and to compare them with IATS unilateral outcomes. DESIGN: Retrospective case series review at 10 IATS sites. PARTICIPANTS: The Toddler Aphakia and Pseudophakia Study (TAPS) is a registry of children treated by surgeons who participated in the IATS. METHODS: Children underwent bilateral cataract surgery with or without intraocular lens (IOL) placement during IATS enrollment years 2004 through\&nbsp;2010. MAIN OUTCOME MEASURES: Visual acuity (VA), strabismus, adverse events (AEs), and reoperations. RESULTS: One hundred seventy-eight eyes (96 children) were identified with a median age of 2.5 months (range, 1-7 months) at the time of cataract surgery. Forty-two eyes (24\%) received primary IOL implantation. Median VA of the better-seeing eye at final study visit closest to 5 years of age with optotype VA testing was 0.35 logarithm of the minimum angle of resolution (logMAR; optotype equivalent, 20/45; range, 0.00-1.18 logMAR) in both aphakic and pseudophakic children. Corrected VA was excellent (\&lt;20/40) in 29\% of better-seeing eyes, 15\% of worse-seeing eyes. One percent showed poor acuity (>=20/200) in the better-seeing eye, 12\% in the worse-seeing eye. Younger age at surgery and smaller (\&lt;9.5 mm) corneal diameter at surgery conferred an increased risk for glaucoma or glaucoma suspect designation (younger age: odds ratio [OR], 1.44; P\&nbsp;= 0.037; and smaller cornea: OR, 3.95; P\&nbsp;= 0.045). Adverse events also were associated with these 2 variables on multivariate analysis (younger age: OR, 1.36; P\&nbsp;= 0.023; and smaller cornea: OR, 4.78; P\&nbsp;= 0.057). Visual axis opacification was more common in pseudophakic (32\%) than aphakic (8\%) eyes (P\&nbsp;= 0.009). Unplanned intraocular reoperation occurred in 28\% of first enrolled eyes (including glaucoma surgery in 10\%). CONCLUSIONS: Visual acuity after bilateral cataract surgery in infants younger than 7 months is good, despite\&nbsp;frequent systemic and ocular comorbidities. Although aphakia management did not affect VA outcome or AE incidence, IOL placement increased the risk of visual axis opacification. Adverse events and glaucoma correlated with a younger age at surgery and glaucoma correlated with the presence of microcornea.},
	issn = {1549-4713},
	doi = {10.1016/j.ophtha.2019.10.039},
	author = {Bothun, Erick D and Wilson, M Edward and VanderVeen, Deborah K and Plager, David A and Freedman, Sharon F and Trivedi, Rupal H and Traboulsi, Elias I and Anderson, Jill S and Loh, Allison R and Yen, Kimberly G and Weil, Natalie C and Morrison, David and Lambert, Scott R}
}
