@article {1517183,
	title = {Cohort Study of Nonmelanoma Skin Cancer and the Risk of Exfoliation Glaucoma},
	journal = {J Glaucoma},
	volume = {29},
	number = {6},
	year = {2020},
	month = {2020 Jun},
	pages = {448-455},
	abstract = {PRECIS: In a cohort study of 120,307 participants with 25+ years of follow-up, a history of nonmelanoma skin cancer (NMSC) was associated with a 40\% higher exfoliation glaucoma (XFG) risk. PURPOSE: The purpose of this study was to evaluate the relationship between NMSC (a marker of ultraviolet radiation exposure) and XFG. METHODS: We performed a cohort study of US women (n=79,102; 1980-2014) and men (n=41,205; 1986-2014), aged 40+ years and at risk for glaucoma who reported eye examinations. From 1984 (women)/1988 (men), we asked about basal cell carcinoma or squamous cell carcinoma history separately; in prior years, we asked about any NMSC history in a single question. Squamous cell carcinoma was confirmed with histopathology reports while basal cell carcinoma and any early (\&lt;1984/\&lt;1988) NMSC history was self-reported. Incident XFG cases (362 women and 83 men) were confirmed with medical records. Using pooled data, we estimated multivariable-adjusted relative risks [MVRRs; 95\% confidence intervals (CIs)] with Cox proportional hazards models that were stratified by age (in mo), 2-year time period at risk and average lifetime residential latitude. RESULTS: In multivariable-adjusted analyses, we observed a 40\% higher XFG risk with any NMSC history (MVRR=1.40; 95\% CI=1.08-1.82); the association was observed even with 4 and 8-year lags in NMSC history. Also, the NMSC association was stronger in younger (below 65 y; MVRR=2.56; 95\% CI=1.62-4.05) versus older participants (65 y and above; MVRR=1.25; 95\% CI=0.94-1.66; P for interaction=0.01) and those living in the northern latitudes (>=42{\textdegree}N; MVRR=1.92; 95\% CI=1.28-2.88) versus more southern latitudes (\&lt;42{\textdegree}N; MVRR=1.19; 95\% CI=0.86-1.66; P for interaction=0.04). CONCLUSION: NMSC was associated with higher XFG risk, particularly among younger participants and those living in the Northern US.},
	issn = {1536-481X},
	doi = {10.1097/IJG.0000000000001496},
	author = {Kang, Jae H and VoPham, Trang and Laden, Francine and Rosner, Bernard A and Wirostko, Barbara and Ritch, Robert and Wiggs, Janey L and Qureshi, Abrar and Nan, Hongmei and Pasquale, Louis R}
}
