@article {1517203,
	title = {In Vivo Quasi-Elastic Light Scattering Eye Scanner Detects Molecular Aging in Humans},
	journal = {J Gerontol A Biol Sci Med Sci},
	volume = {75},
	number = {9},
	year = {2020},
	month = {2020 Sep 16},
	pages = {e53-e62},
	abstract = {The absence of clinical tools to evaluate individual variation in the pace of aging represents a major impediment to understanding aging and maximizing health throughout life. The human lens is an ideal tissue for quantitative assessment of molecular aging in vivo. Long-lived proteins in lens fiber cells are expressed during fetal life, do not undergo turnover, accumulate molecular alterations throughout life, and are optically accessible in vivo. We used quasi-elastic light scattering (QLS) to measure age-dependent signals in lenses of healthy human subjects. Age-dependent QLS signal changes detected in vivo recapitulated time-dependent changes in hydrodynamic radius, protein polydispersity, and supramolecular order of human lens proteins during long-term incubation (~1 year) and in response to sustained oxidation (~2.5 months) in vitro. Our findings demonstrate that QLS analysis of human lens proteins provides a practical technique for noninvasive assessment of molecular aging in vivo.},
	issn = {1758-535X},
	doi = {10.1093/gerona/glaa121},
	author = {Minaeva, Olga and Sarangi, Srikant and Ledoux, Danielle M and Moncaster, Juliet A and Parsons, Douglas S and Washicosky, Kevin J and Black, Caitlin A and Weng, Frank J and Ericsson, Maria and Moir, Robert D and Tripodis, Yorghos and Clark, John I and Tanzi, Rudolph E and Hunter, David G and Goldstein, Lee E}
}
