@article {1517211,
	title = {Twenty-four Month Outcomes in the Collaborative Ocular Tuberculosis Study (COTS)-1: Defining the "Cure" in Ocular Tuberculosis},
	journal = {Ocul Immunol Inflamm},
	year = {2020},
	month = {2020 Jun 26},
	pages = {1-9},
	abstract = {PURPOSE: To report the clinical findings, anatomical features, and treatment outcomes in subjects with ocular tuberculosis (OTB) at 24\&nbsp;months in the Collaborative Ocular Tuberculosis Study (COTS)-1. METHODS: Of the 945 subjects included in COTS-1, those who completed a 24-month follow-up after completion of treatment were included. The main outcome measure was a number of patients with treatment failure (TF). RESULTS: 228 subjects (120 males; mean age of 42.82\&nbsp;{\textpm}\&nbsp;14.73\&nbsp;years) were included. Most common phenotype of uveitis was posterior ( =\&nbsp;81; 35.53\%), and panuveitis ( =\&nbsp;76; 33.33\%). Fifty-two patients (22.81\%) had TF. On univariable analysis, odds of high TF was observed with bilaterality (OR: 3.46, =\&nbsp;.003), vitreous haze (OR: 2.14, =\&nbsp;.018), and use of immunosuppressive therapies (OR: 5.45, =\&nbsp;.003). However, only bilaterality was significant in the multiple regression model (OR: 2.84; =\&nbsp;.02). CONCLUSIONS: Majority of subjects (\&gt;75\%) achieved cure in the COTS-1 at 24-month follow-up. The concept of "cure" may be a valuable clinical endpoint in trials for OTB.},
	issn = {1744-5078},
	doi = {10.1080/09273948.2020.1761401},
	author = {Agarwal, Aniruddha and Agrawal, Rupesh and Raje, Dhananjay and Testi, Ilaria and Mahajan, Sarakshi and Gunasekeran, Dinesh Visva and Aggarwal, Kanika and Murthy, Somasheila I and Westcott, Mark and Chee, Soon-Phaik and McCluskey, Peter and Ho, Su Ling and Teoh, Stephen and Cimino, Luca and Biswas, Jyotirmay and Narain, Shishir and Agarwal, Manisha and Mahendradas, Padmamalini and Khairallah, Moncef and Jones, Nicholas and Tugal-Tutkun, Ilknur and Babu, Kalpana and Basu, Soumayava and Carre{\~n}o, Ester and Lee, Richard and Al-Dhibi, Hassan and Bodaghi, Bahram and Invernizzi, Alessandro and Goldstein, Debra A and Herbort, Carl P and Barisani-Asenbauer, Talin and Gonz{\'a}lez-L{\'o}pez, Julio J and Androudi, Sofia and Bansal, Reema and Moharana, Bruttendu and Esposti, Simona Degli and Tasiopoulou, Anastasia and Nadarajah, Sengal and Agarwal, Mamta and Abraham, Sharanaya and Vala, Ruchi and Singh, Ramandeep and Sharma, Aman and Sharma, Kusum and Zierhut, Manfred and Kon, Onn Min and Cunningham, Emmett T and Kempen, John H and Nguyen, Quan Dong and Pavesio, Carlos and Gupta, Vishali}
}
