@article {1522723,
	title = {Exudative Retinal Detachment in Ocular Inflammatory Diseases: Risk and Predictive Factors},
	journal = {Am J Ophthalmol},
	volume = {218},
	year = {2020},
	month = {2020 Oct},
	pages = {279-287},
	abstract = {PURPOSE: This study evaluated the risk and risk factors for exudative retinal detachment (ERD) in ocular inflammatory diseases. DESIGN: Retrospective cohort study. METHODS: Patients with noninfectious ocular inflammation had been followed longitudinally between 1978 and 2007 at 4\&nbsp;US subspecialty uveitis centers. The main outcome measurements were occurrences of ERD and predictive factors. RESULTS: A total of 176 of 14,612 eyes with ocular inflammation presented with ERD. Among uveitis cases, Vogt-Koyanagi-Harada syndrome (VKH) (odds ratio [OR]\&nbsp;= 109), undifferentiated choroiditis (OR\&nbsp;= 9.18), sympathetic ophthalmia (OR\&nbsp;= 8.43), primary or secondary panuveitis (OR\&nbsp;= 7.09), multifocal choroiditis with panuveitis (OR\&nbsp;= 4.51), and "other" forms of posterior uveitis (OR\&nbsp;= 16.9) were associated with a higher prevalence of ERD. Among the 9,209 uveitic or scleritic eyes initially free of ERD and followed, 137 incident ERD cases were observed over 28,949 eye-years at risk (incidence rate\&nbsp;= 0.47\% [0.40\%-0.56\%/eye-year]). VKH (HR\&nbsp;= 13.2), sympathetic ophthalmia (HR\&nbsp;= 5.82), undifferentiated choroiditis (HR\&nbsp;= 6.03), primary or secondary panuveitis (HR\&nbsp;= 4.21), and rheumatoid arthritis (HR\&nbsp;= 3.30) were significantly associated with incident ERD. A significant dose-response relationship with the prevalence and incidence of ERD were observed for AC cells and vitreous cell activity. African Americans had significantly higher prevalence and incidence of ERD. CONCLUSIONS: Other ocular inflammatory conditions in addition to VKH syndrome and posterior scleritis were associated with increased risk of ERD, indicating that ERD does not necessarily dictate a diagnosis of VKH or posterior scleritis. In addition, the relationship between ERD and inflammatory severity factors implies that inflammation is a key predictive factor associated with developing ERD and requires early and vigorous control.},
	issn = {1879-1891},
	doi = {10.1016/j.ajo.2020.06.019},
	author = {Shah, Deepika N and Al-Moujahed, Ahmad and Newcomb, Craig W and Ka{\c c}maz, R Oktay and Daniel, Ebenezer and Thorne, Jennifer E and Foster, C Stephen and Jabs, Douglas A and Levy-Clarke, Grace A and Nussenblatt, Robert B and Rosenbaum, James T and Sen, H Nida and Suhler, Eric B and Bhatt, Nirali P and Kempen, John H and Systemic Immunosuppressive Therapy for Eye Diseases Research Group}
}
