@article {1522731,
	title = {Outcomes of Bilateral Cataract Surgery in Infants 7 to 24 Months of Age Using the Toddler Aphakia and Pseudophakia Treatment Study Registry},
	journal = {Ophthalmology},
	volume = {128},
	number = {2},
	year = {2021},
	month = {2021 Feb},
	pages = {302-308},
	abstract = {PURPOSE: To evaluate outcomes of bilateral cataract surgery in children aged 7 to 24 months and compare rates of adverse events (AEs) with other Toddler Aphakia and Pseudophakia Study (TAPS) registry outcomes. DESIGN: Retrospective clinical study at 10 Infant Aphakia Treatment Study (IATS) sites. Statistical analyses comparing this cohort with previously reported TAPS registry cohorts. PARTICIPANTS: Children enrolled in the TAPS registry between 2004 and\&nbsp;2010. METHODS: Children underwent bilateral cataract surgery with or without intraocular lens (IOL) placement at age 7 to 24 months with 5 years of postsurgical follow-up. MAIN OUTCOME MEASURES: Visual acuity (VA), occurrence of strabismus, AEs, and reoperations. RESULTS: A total of 40 children (76 eyes) who underwent bilateral cataract surgery with primary posterior capsulectomy were identified with a median age at cataract surgery of 11 months (7-23); 68\% received a primary IOL. Recurrent visual axis opacification (VAO) occurred in 7.5\% and was associated only with the use of an IOL (odds ratio, 6.10; P\&nbsp;= 0.005). Glaucoma suspect (GS) was diagnosed in 2.5\%, but no child developed glaucoma. In this bilateral cohort, AEs (8/40, 20\%), including glaucoma or GS and VAO, and reoperations occurred in a similar proportion to that of the published unilateral TAPS cohort. When analyzed with children aged 1 to 7 months at bilateral surgery, the incidence of AEs and glaucoma or GS correlated strongly with age at surgery (P\&nbsp;=\&nbsp;0.011/0.004) and glaucoma correlated with microcornea (P\&nbsp;= 0.040) but not with IOL insertion (P\&nbsp;= 0.15). CONCLUSIONS: Follow-up to age 5 years after bilateral cataract surgery in children aged 7 to 24 months reveals a low rate of VAO and very rare glaucoma or GS diagnosis compared with infants with cataracts operated at \&lt; 7 months of age despite primary IOL implantation in most children in the group aged 7 to 24 months. The use of an IOL increases the risk of VAO irrespective of age at surgery.},
	issn = {1549-4713},
	doi = {10.1016/j.ophtha.2020.07.020},
	author = {Bothun, Erick D and Wilson, M Edward and Yen, Kimberly G and Anderson, Jill S and Weil, Natalie C and Loh, Allison R and Morrison, David and Freedman, Sharon F and Plager, David A and VanderVeen, Deborah K and Traboulsi, Elias I and Hodge, David O and Lambert, Scott R and Toddler Aphakia and Pseudophakia Study}
}
