@article {1528427,
	title = {A connectomics approach to understanding a retinal disease},
	journal = {Proc Natl Acad Sci U S A},
	volume = {117},
	number = {31},
	year = {2020},
	month = {2020 Aug 04},
	pages = {18780-18787},
	abstract = {Macular telangiectasia type 2 (MacTel), a late-onset macular degeneration, has been linked to a loss in the retina of M{\"u}ller glial cells and the amino acid serine, synthesized by the M{\"u}ller cells. The disease is confined mainly to a central retinal region called the MacTel zone. We have used electron microscopic connectomics techniques, optimized for disease analysis, to study the retina from a 48-y-old woman suffering from MacTel. The major observations made were specific changes in mitochondrial structure within and outside the MacTel zone that were present in all retinal cell types. We also identified an abrupt boundary of the MacTel zone that coincides with the loss of M{\"u}ller cells and macular pigment. Since M{\"u}ller cells synthesize retinal serine, we propose that a deficiency of serine, required for mitochondrial maintenance, causes mitochondrial changes that underlie MacTel development.},
	issn = {1091-6490},
	doi = {10.1073/pnas.2011532117},
	author = {Zucker, Charles L and Bernstein, Paul S and Schalek, Richard L and Lichtman, Jeff W and Dowling, John E}
}
