@article {1528428, title = {The Collaborative Ocular Tuberculosis Study (COTS)-1: A Multinational Descriptive Review of Tubercular Uveitis in Paediatric Population}, journal = {Ocul Immunol Inflamm}, year = {2020}, month = {2020 Aug 17}, pages = {1-7}, abstract = {PURPOSE: To examine disease profile of tubercular uveitis (TBU) in Paediatric population. METHODS: Among 945 patients of the retrospective multinational study by the Collaborative Ocular Tuberculosis Study (COTS)-1, 29 Paediatric patients diagnosed with TBU were analyzed. RESULTS: Mean age of disease presentation was 12.8 (range 4-18\ years), with predominance of males (n\ =\ 14/20; 70.0\%) and Asian ethnicity (n\ =\ 25/29; 86.2\%). Posterior uveitis (n\ =\ 14/28; 50\%) was the most frequent uveitis phenotype, with choroidal involvement occurring in 64.7\% (n\ =\ 11/17). Incidence of optic disc edema and macular edema was higher in children (n\ =\ 8/18; 44.4\% and n =\ 5/18; 27.8\%, respectively) than in adults (n\ =\ 160/942; 16.9\% and n =\ 135/942; 14.3\%, respectively). Comparison of optic disc edema between subgroups showed a significant difference (). All patients received oral corticosteroids, most of them with antitubercular therapy. Treatment failure developed in 4.8\% (n\ =\ 1/21). CONCLUSIONS: Children have a more severe inflammatory response to the disease, and an intensive anti-inflammatory therapeutic regimen is required to achieve a positive treatment outcome.}, issn = {1744-5078}, doi = {10.1080/09273948.2020.1781197}, author = {Testi, Ilaria and Agrawal, Rupesh and Mahajan, Sarakshi and Agarwal, Aniruddha and Gunasekeran, Dinesh Visva and Raje, Dhananjay and Aggarwal, Kanika and Murthy, Somasheila I and Westcott, Mark and Chee, Soon-Phaik and McCluskey, Peter and Ho, Su Ling and Teoh, Stephen and Cimino, Luca and Biswas, Jyotirmay and Narain, Shishir and Agarwal, Manisha and Mahendradas, Padmamalini and Khairallah, Moncef and Jones, Nicholas and Tugal-Tutkun, Ilknur and Babu, Kalpana and Basu, Soumayava and Carre{\~n}o, Ester and Lee, Richard and Al-Dhibi, Hassan and Bodaghi, Bahram and Invernizzi, Alessandro and Goldstein, Debra A and Herbort, Carl P and Barisani-Asenbauer, Talin and Gonz{\'a}lez-L{\'o}pez, Julio J and Androudi, Sofia and Bansal, Reema and Moharana, Bruttendu and Esposti, Simona Degli and Tasiopoulou, Anastasia and Nadarajah, Sengal and Agarwal, Mamta and Abraham, Sharanaya and Vala, Ruchi and Singh, Ramandeep and Sharma, Aman and Sharma, Kusum and Zierhut, Manfred and Kon, Onn Min and Cunningham, Emmett T and Kempen, John H and Nguyen, Quan Dong and Pavesio, Carlos and Gupta, Vishali} }