@article {1532330,
	title = {Characterization of Resident Corneal Plasmacytoid Dendritic Cells and Their Pivotal Role in Herpes Simplex Keratitis},
	journal = {Cell Rep},
	volume = {32},
	number = {9},
	year = {2020},
	month = {2020 Sep 01},
	pages = {108099},
	abstract = {The presence and potential functions of resident plasmacytoid dendritic cells (pDCs) in peripheral tissues is unclear. We report that pDCs constitutively populate na{\"\i}ve corneas and are increased during sterile injuries or acute herpes simplex virus 1 (HSV-1) keratitis. Their local depletion leads to severe clinical disease, nerve loss, viral dissemination to the trigeminal ganglion and draining lymph nodes, and mortality, while their local adoptive transfer limits disease. pDCs are the main source of HSV-1-induced IFN-α in the corneal stroma through TLR9, and they prevent re-programming of regulatory T\&nbsp;cells (Tregs) to effector ex-Tregs. Clinical signs of infection are observed in pDC-depleted corneas, but not in pDC-sufficient corneas, following low-dose HSV-1 inoculation, suggesting their critical role in corneal antiviral immunity. Our findings demonstrate a vital role for corneal pDCs in the control of local viral infections.},
	issn = {2211-1247},
	doi = {10.1016/j.celrep.2020.108099},
	author = {Jamali, Arsia and Hu, Kai and Sendra, Victor G and Blanco, Tomas and Lopez, Maria J and Ortiz, Gustavo and Qazi, Yureeda and Zheng, Lixin and Turhan, Aslihan and Harris, Deshea L and Hamrah, Pedram}
}
