@article {1532379,
	title = {Artifact Rates for 2D Retinal Nerve Fiber Layer Thickness Versus 3D Neuroretinal Rim Thickness Using Spectral-Domain Optical Coherence Tomography},
	journal = {Transl Vis Sci Technol},
	volume = {9},
	number = {10},
	year = {2020},
	month = {2020 Sep},
	pages = {10},
	abstract = {Purpose: To compare the rates of clinically significant artifacts for two-dimensional peripapillary retinal nerve fiber layer (RNFL) thickness versus three-dimensional (3D) neuroretinal rim thickness using spectral-domain optical coherence tomography (SD-OCT). Methods: Only one eye per patient was used for analysis of 120 glaucoma patients and 114 normal patients. For RNFL scans and optic nerve scans, 15 artifact types were calculated per B-scan and per eye. Neuroretinal rim tissue was quantified by the minimum distance band (MDB). Global MDB neuroretinal rim thicknesses were calculated before and after manual deletion of B-scans with artifacts and subsequent automated interpolation. A clinically significant artifact was defined as one requiring manual correction or repeat scanning. Results: Among glaucomatous eyes, artifact rates per B-scan were significantly more common in RNFL scans (61.7\%, 74 of 120) compared to B-scans in neuroretinal rim volume scans (20.9\%, 1423 of 6820) (95\% confidence interval [CI], 31.6-50.0; \&lt; 0.0001). For clinically significant artifact rates per eye, optic nerve scans had significantly fewer artifacts (15.8\% of glaucomatous eyes, 13.2\% of normal eyes) compared to RNFL scans (61.7\% of glaucomatous eyes, 25.4\% of normal eyes) (glaucoma group: 95\% CI, 34.1-57.5, \&lt; 0.0001; normal group: 95\% CI, 1.3-23.3, = 0.03). Conclusions: Compared to the most commonly used RNFL thickness scans, optic nerve volume scans less frequently require manual correction or repeat scanning to obtain accurate measurements. Translational Relevance: This paper illustrates the potential for 3D OCT algorithms to improve in vivo imaging in glaucoma.},
	issn = {2164-2591},
	doi = {10.1167/tvst.9.10.10},
	author = {Park, Elli A and Tsikata, Edem and Lee, Jenny Jyoung and Shieh, Eric and Braaf, Boy and Vakoc, Benjamin J and Bouma, Brett E and de Boer, Johannes F and Chen, Teresa C}
}
